RSS 1.0Griffith Research Online
Griffith Research Online (GRO) is a digital archive of research and scholarship from Griffith University, Brisbane, Australia.
GRO delivers free online full-text versions of journal articles, conference papers, and more, where this is possible with the appropriate permissions of copyright owners. GRO increases the impact and influence of Griffith research and scholarship by ensuring it is visible, discoverable and accessible via search engines like Google and discovery services like the National Library’s Trove.
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The biochemical and molecular mechanisms involved in the role of tumor micro-environment stress in development of drug resistance
(Biochimica et Biophysica Acta (BBA) - General Subjects, 2019)Background: Multi-drug resistance (MDR) is a leading cause of morbidity and mortality in cancer and it continues to be a challenge in cancer treatment. Moreover, the tumor micro-environment is essential to the formation ...JOURNAL ARTICLE -
Tumor-induced neoangiogenesis and receptor tyrosine kinases - Mechanisms and strategies for acquired resistance
(Biochimica et Biophysica Acta (BBA) - General Subjects, 2019)Background: Angiogenesis is essential for tumor growth, proliferation and metastasis. Tumor-related angiogenesis is complex and involves multiple signaling pathways. Controlling angiogenesis is a promising strategy for ...JOURNAL ARTICLE -
Targeting Oncogenic Nuclear Factor Kappa B Signaling with Redox-Active Agents for Cancer Treatment
(Antioxidants & Redox Signaling, 2018)Significance: Nuclear factor kappa B (NF-κB) signaling is essential under physiologically relevant conditions. However, aberrant activation of this pathway plays a pertinent role in tumorigenesis and contributes to resistance. ...JOURNAL ARTICLE -
Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies
(Pharmacological Research, 2019)Mitochondria play vital roles in various cellular processes, ranging from cellular metabolism to signal transduction and cell death regulation. As these properties are critical for cancer growth, the mitochondrion has ...JOURNAL ARTICLE -
Ironing out the role of the cyclin-dependent kinase inhibitor, p21 in cancer: Novel iron chelating agents to target p21 expression and activity
(Free Radical Biology and Medicine, 2019)Iron (Fe) has become an important target for the development of anti-cancer therapeutics with a number of Fe chelators entering human clinical trials for advanced and resistant cancer. An important aspect of the activity ...JOURNAL ARTICLE