Now showing items 61-80 of 59971

    • 1H NMR Spectroscopic Studies Establish that Heparanase is a Retaining Glycosidase 

      Wilson, Jenny; Laloo, Andrew Elohim; Singh, Sanjesh; Ferro, Vito (Biochemical and Biophysical Research Communications, 2013)
      Heparanase is an endo-߭glucuronidase that cleaves heparan sulfate side chains of proteoglycans in basement membranes and the extracellular matrix (ECM). Heparanase is implicated in several diverse pathological processes ...
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    • 1H NMR-based metabolomics reveals sub-lethal toxicity of a mixture of diabetic and lipid-regulating pharmaceuticals on amphibian larvae 

      Melvin, Steve; Habener, Leesa; Leusch, Frederic; Carroll, Anthony (Aquatic Toxicology, 2017)
      Pharmaceuticals are widely used for the treatment of various physical and psychological ailments. Due to incomplete removal during sewage treatment many pharmaceuticals are frequently detected in aquatic waterways at trace ...
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    • A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase 

      Haselhorst, Thomas; Oschlies, Melanie; Abu-Izneid, Tareq; Kiefel, Milton; Tiralongo, Joe; K. Münster-Kühnel, Anja; Gerardy-Schahn, Rita; von Itzstein, Mark (Glycoconjugate Journal, 2006)
      CMP-Kdn synthetase catalyses the reaction of sialic acids (Sia) and CTP to the corresponding activated sugar nucleotide CMP-Sia and pyrophosphate PP i . Saturation Transfer Difference (STD) NMR spectroscopy has been employed ...
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    • [1H, 15N] heteronuclear single quantum coherence NMR study of the mechanism of aquation of platinum(IV) ammine complexes. 

      Davies, Murray; Hall, Matthew; Berners-Price, Sue; Hambley, Trevor (Inorganic Chemistry, 2008)
      The aquation and hydrolysis of a series of platinum(IV) complexes of the general form cis, trans, cis-[PtCl 2(X) 2( (15)NH 3) 2] (X = Cl (-), O 2CCH 3 (-), OH (-)) have been followed by [ (1)H, (15)N] Heteronuclear Single ...
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    • [1H, 15N] NMR Investigations of Pt-NH Hydrogen Bonding in d(GpG), d(pGpG), and d(TpGpG)-N7,N7 Adducts of [Pt(en)]2+ in Aqueous Solution 

      Berners-Price, Sue; Ranford, J.; Sadler, P. (Inorganic Chemistry, 1994)
      We report studies of the pH and temperature dependences of N-H NMR resonances of [Pt(15N-en){d(GpG)­N7(1 ),N7(2)} ]2+ (1), [Pt(15N-en){ d(pGpG)-N7(1 ),N7(2)} ]2+ (2), and [Pt(15N-en){ d(TpGpG)-N7(2),N7(3)} ]2+ (3) in ...
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    • [1H,15N] NMR studies of the aquation of cis-diamine platinum(II) complexes 

      Cubo, Leticia; Thomas, Donald S.; Zhang, Junyong; Quiroga, Adoración G.; Navarro-Ranninger, Carmen; Berners-Price, Sue (Inorganica Chimica Acta, 2009)
      Two 15N-labelled cis-Pt(II) diamine complexes with dimethylamine (15N-dma) and isopropylamine (15N-ipa) ligands have been prepared and characterised. [1H,15N] HSQC NMR spectroscopy is used to obtain the rate and equilibrium ...
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    • (1R,2S,3R,6S,7R,8S)-Tricyclo[6.2.1.02,7]undeca-4,9-diene-3,6-diol 

      D. Banister, Samuel; K. Clegg, Jack; J. Coster, Mark; A. Jolliffe, Katrina; Kassiou, Michael (Acta crystallographica. Section E, Structure reports online, 2007)
      The asymmetric unit of the title compound, C11H14O2, contains two molecules. The alcohol groups have cis stereochemistry and are involved in hydrogen bonding (acting as both donors and acceptors), resulting in the formation ...
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    • (1RS,2RS,6SR,8SR)-2-methyl-8-(phenylsulfonyl)bicyclo[4.2.0]octan-1-ol 

      Loughlin, Wendy; McCleary, Michelle; Healy, Peter (ACTA Crystallographica Section E - Structure Reports Online, 2004)
      The title compound, C15H20O3S, shows a conformational arrangement of the phenyl ring that permits hydrogen-bonded dimers to be disposed about a centre of symmetry.
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    • (1RS,2SR,6SR,8SR)-2,6-dimethyl-8-(phenylsulfonyl)bicyclo[4.2.0]octan-1-ol 

      Loughlin, Wendy; McCleary, Michelle; Healy, Peter (ACTA Crystallographica Section E - Structure Reports Online, 2004)
      The title compound, C16H22O3S, exhibits a conformational arrangement that permits intramolecular O-HO-S hydrogen bonds. Intermolecular bifurcated hydorgen bonding between the hydroxyl H and the sulfone O atoms, observed ...
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    • 2'-OMe-phosphorodithioate modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity 

      Y. Wu, Sherry; Yang, Xianbin; M. Gharpure, Kshipra; Hatakeyama, Hiroto; Egli, Martin; H. McGuire, Michael; S. Nagaraja, Archana; M. Miyake, Takahito; Rupaimoole, Rajesha; V. Pecot, Chad; Taylor, Morgan; Pradeep, Sunila; Sierant, Malgorzata; Rodriguez-Aguayo, Cristian; J. Choi, Hyun; A. Previs, Rebecca; N. Armaiz-Pena, Guillermo; Huang, Li; Martinez, Carlos; Hassell, Tom; Ivan, Cristina; Sehgal, Vasudha; Singhania, Richa; Han, Hee-Dong; Su, Chang; Kim, Ji Hoon; J. Dalton, Heather; Kovvali, Chandra; Keyomarsi, Khandan; McMillan, Nigel; al, et (Nature Communications, 2014)
      Improving small interfering RNA (siRNA) efficacy in target cell populations remains a challenge to its clinical implementation. Here, we report a chemical modification, consisting of phosphorodithioate (PS2) and 2'-O-Methyl ...
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    • 2,2-dichloro-6-methoxy-3,4-dihydro-2H-naphthalene 

      Brown, Chris; Freiberg, James; Healy, Peter (ACTA Crystallographica Section E - Structure Reports Online, 2002)
      The structure of the title compound, C11H10Cl2O2, shows that the asymmetric unit contains two closely related independent molecules that pack in a head-to-tail arrangement.
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    • 2,3-Dimeth oxy-10-oxostrychnidinium 3-carboxy benzoate trihydrate: the 1:1 proton-transfer compound of brucine with isophthalic acid 

      Smith, Graham; Wermuth, Urs; Young, David; M. White, Johnathan (Acta Crystallographica Section E, 2006)
      The structure of the title, compound C23H27N2O4+烸H5O4糈2O, has been determined at 130 K. The hydrogen isophthalate anions and the water mol�ules (one of which is disordered over two approximately equal sites) associate ...
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    • 2,3-Dimethoxy-10-oxostrychnidinium 2-carboxy-4,5-dichlorobenzoate 

      Smith, Graham; Wermuth, Urs; M. White, Jonathan (Acta Crystallographica Section E, Structure Reports Online, 2007)
      The structure of the title compound, C23H27N2O4+烸H3Cl2O4-, a 1:1 proton-transfer compound of brucine with 4,5-dichlorophthalic acid, has been determined at 130 K. The brucinium cations and the hydrogen phthalate anions ...
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    • (2,4,6-Trinitrophenyl)guanidine 

      Smith, Graham; Wermuth, Urs; M. White, Jonathan (Acta Crystallographica Section E, Structure Reports Online, 2007)
      (2,4,6-Trinitrophenyl)guanidine (picrylguanidine), C7H6N6O6, from the reaction of picrylsulfonic acid with guanidine carbonate, forms a three-dimensional framework structure through extensive hydrogen-bonding interactions, ...
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    • 2,4-Diaminothienopyrimidines as orally active antimalarial agents 

      Cabrera, Diego González; Manach, Claire; Douelle, Frederic; Younis, Yassir; Feng, Tzu-Shean; Paquet, Tanya; T. Nchinda, Aloysius; J. Street, Leslie; Taylor, Dale; Kock, Carmen; Wiesner, Lubbe; Duffy, Sandra; L. White, Karen; Mohammed Zabiulla, K.; Sambandan, Yuvaraj; Bashyam, Sridevi; Waterson, David; J. Witty, Michael; A. Charman, Susan; Avery, Vicky; Wittlin, Sergio (Journal of Medicinal Chemistry, 2014)
      A novel series of 2,4-diaminothienopyrimidines with potential as antimalarials was identified from whole-cell high-throughput screening of a SoftFocus ion channel library. Synthesis and structure–activity relationship ...
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    • 2,6-dimethyl-2-[2'(phenylsulfonyl)ethyl]cyclohexanone 

      Loughlin, Wendy; McCleary, Michelle; Healy, Peter (ACTA Crystallographica Section E - Structure Reports Online, 2002)
      The structure of the title compound, C16H22O3S, shows the phenylsulfonylethyl side chain to be in the equatorial orientation.
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    • 2-(2,4-Dinitrobenzyl)pyridinium 2-hydroxy-3,5-dinitrobenzoate 

      Smith, Graham; D. Wermuth, Urs; Young, David (Acta Crystallographica. Section E: Structure Reports Online, 2010)
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    • 2-(3-Chloro-4-hydroxylphenyl)-N-(3,4-dimethyoxyphenethyl)acetamide 

      Davis, Rohan; Healy, Peter (Acta Crystallographica. Section E: Structure reports online, 2008)
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    • 2-[2'-(Phenylsulfonyl)ethyl]cyclopentanone 

      Loughlin, Wendy; McCleary, Michelle; Healy, Peter (ACTA Crystallographica Section E - Structure Reports Online, 2002)
      The structure of the title compound, C13H16O3S, prepared by the reaction of the lithium enolate of cyclopentanone with phenylvinyl sulfoxide and subsequent oxidation with m-chloroperoxybenzoic acid (m-CPBA), shows the ...
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    • 2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers 

      Nikolakopoulos, George; Figler, Heidi; Linden, Joel; J. Scammells, Peter (Bioorganic & Medicinal Chemistry, 2006)
      Three series of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene and 2-amino-5,6,7,8-tetrahydrocyclohepta[b]thiophenes with 3-carboxylates and carboxamides have been prepared using the Gewald synthesis and evaluated as A1AR ...
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