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Patent Dynamically adjustable training simulationRoberts, Melanie; Hickson, Roslyn I; Smith, Olivia J; Gambhir, Manoj; International Business Machines Corporation (2020-06-04)Systems, methods and program products for administering and modifying a simulation that incorporates the use of biometric data collection and computer-based predictive modeling techniques to reliably identify changes in the stress level of simulation participants while predictively adapting the simulation environment to manage each participants' stress levels within a pre-set or desired range. Each participant may have their biometric data collected and continuously monitored by wearing a computing device comprising biometric sensors, camera systems and audio recording devices. As the participants biometric data changes, the system monitors the participant for changes in stress level and maintains a desired stress level in the participant by modifying the adjustable properties of one or more virtual objects or computer-accessible real physical objects of the simulation environment to increase or decrease the stress level of the simulation on participants.
Patent Mitochondrially delivered anti-cancer compoundsRalph, Stephen; Neuzil, Jiri; Sillins, Gint (2019)This invention relates to anti - cancer compounds and to methods for treating or preventing cancer . In one aspect the invention concerns mitochondrially delivered pro - oxidant anti - cancer compounds that generate reactive oxygen spe cies and induce apoptosis of cancerous cells . The delivery moiety can be a lipophilic cation and the pro - oxidant moiety can be a pro - oxidant vitamin E analogue , such as a - tocoph eryl succinate , a - tocopheryl maleate , a - tocopheryl maleyl amide , or 2 , 5 , 7 , 8 - tetramethyl - 2R - ( 4R , 8R , 12 - trimethyltride cyl ) - chroman - 6 - yloxyacetic acid ( a - tocopheryloxyacetic acid ) .
Patent Agents and compositions for eliciting an immune responseRalph, Stephen; Arget, Victor (2021)Immune-potentiating compositions include cells exhibiting enhanced antigen-presenting functions. The compositions are generally useful in facilitating the stimulation of host immune cell responses, including selective and targeted immune cell responses, and are particularly useful in the treatment and/or prophylaxis of cancers, tumors and pathogenic infections.
Patent Synthesis of functionalised gold nanoparticles and nanocompounds containing same for measuring sucrose or starch in cellsHermith-Ramirez, Diana-Patricia; Jaramillo Botero, Andres; Hernandez, Pedro (2022)The present invention relates to the field of industrial processes for measuring sugars and starch in cells and concerns the process of functionalising synthesized gold nanoparticles functionalized with polymer ligands, for the selective measurement of sucrose or starch in intracellular fluid. Also disclosed is a nanocompound for measuring the concentration of sucrose or starch in intracellular fluid, which contains synthesized gold nanoparticles functionalized with polymer ligands.
Patent Method and system of manufacturing a load-bearing structure and a load-bearing structure manufactured thereofDaynes, Stephen; Feih, Stefanie; Wei, Jun (2017)A method of manufacturing a load-bearing structure. The method may include establishing overall dimensions and expected loading conditions of the load-bearing structure; determining a material density distribution within a solid model for the load-bearing structure based on the overall dimensions and the expected loading conditions for a predetermined objective end constraint; generating stress field data for the determined material density distribution based on the expected loading conditions; transforming the solid model into a spatially-graded mesh model having a plurality of three-dimensional cells based on orthogonal isostatic lines populated along principal stress directions of the stress field data;; and fabricating the load-bearing structure with truss members aligned according to the spatially-graded mesh model. A system for manufacturing a load-bearing structure and a load-bearing structure manufactured thereof.
Patent Apparatus for maintaining a pressure different from atmospheric pressure, methods of forming and operating the sameIsakov, Dmitry; Vong, Siew Soon; Huang Ming, Chong; Feih, Stefanie (2018)Various embodiments may provide an apparatus for maintaining a pressure different from atmospheric pressure. The apparatus may include a plurality of structural members coupled together to at least partially define a space which is configured to have a pressure different from atmospheric pressure, a structural member of the plurality of structural members being a support structure having an array of holes. The apparatus may also include a film covering a surface of the support structure having an array of holes. The film maybe adapted to allow a predetermined range of wavelengths of electromagnetic waves to pass through.
Patent Streptococcal Toxic Shock SyndromePandey, Manisha; Good, Michael (2019)This invention relates to prevention and treatment of diseases caused by group A streptococci. More particularly, this invention relates to an antibodies or antibody fragments for treating or preventing group A streptococcus-associated toxic shock syndrome.
Provided herein are methods of immunizing against, treating or preventing streptococcal toxic shock syndrome in a subject, by administration of a group Astreptococcus M protein, inclusive of fragments, variants or derivatives thereof, or an antibody that binds, or is raised against the M protein and optionally a group A streptococcus superantigen protein, inclusive of fragments, variants or derivatives thereof, or an antibody or antibody fragment that binds, or is raised against, the superantigen protein.
Patent Bionic collar for enhancing targeted drug delivery into thyroid cancer through magnetic targeting and oscillation methodAriana, Armin (2016)The present invention is a wearable neck collar with built in magnetic field and ultrasonic compartments. The activation of magnetic field and ultrasound are controlled by the user for the purpose of targeting thyroid cancer and delivery of any novel treatment. This bionic collar is designed for patients with thyroid cancer to receive a novel targeted anti-cancer treatment in their home or in an oncology/endocrinology department or any health care unit that looks after thyroid cancer patients. The above mentioned medication is a novel targeted anti-cancer treatment, known as magnetic microbubbles, was described previously (referenced) and the current innovation assist the delivery of that kind of medication and treatment.
Patent Facilitated online brainstorming toolLangham, Jo'Anne; Sparktank Technologies Pty Ltd (2021-12-30)A facilitated online ideation (e.g. brainstorming) method and system is provided that is efficient and easy to use, and without requiring a facilitator, or participants with specialised training or experience. The method includes receiving, on a data interface, details of a challenge; receiving, on the data interface, a plurality of focus areas relating to the challenge; and automatically allocating participants to each of the plurality of focus areas. Ideas relating to an allocated focus area of each of the participants are received, on the data interface, and from each of the participants, and participants are automatically allocated to ideas for review of the ideas.
Patent Brain Activity MonitoringDe Souza Junior, Paulo; Guvenc, Umut; Iji, Ayobami (2019)A system for monitoring brain activity of a subject, including an implantable measurement device including: a sensor configured to measure electrical activity in the brain; electronic measurement processing devices configured to: receive measurement data from the sensor; use the measurement data to determine if the brain activity of the subject is indicative of an event; and generate event data indicative of the brain activity associated with the event; and an implantable transceiver configured to transmit the event data; an inductive implantable coil configured to inductively receive power; and an external monitoring device including: an external transceiver configured to receive event data from the implantable measurement device; an inductive external coil configured to inductively transmit power to the implantable measurement device; and electronic monitoring processing devices configured to: generate subject data; and transfer the subject data to analysis processing devices for analysis.
Patent A luminescent photonic structure, a method of fabricating a luminescent photonic structure, and a method of sensing a chemical substanceEftekhari, Ehsan; Li, Qin; Kielpinski, David (2017)Disclosed herein is a luminescent photonic structure (10). The luminescent photonic structure (10) comprises a luminescent material (14) that when excited by an excitation light (11) having a wavelength within an excitation wavelength spectrum of the luminescent material (14) emits luminescent light having a luminescence wavelength spectrum. The luminescent photonic structure (10) comprises a photonic crystal (14) disposed between two other photonic crystals (12,16). The photonic crystal (14) has a photonic lattice period within one of the luminescence wavelength spectrum and the excitation wavelength spectrum. The two other photonic crystals (12,16) each have a photonic lattice period within the other of the luminescence wavelength spectrum and the excitation wavelength spectrum for reflecting one of excitation light and luminescent light propagating within the photonic crystal (12). Also disclosed herein is a method for fabricating a luminescent photonic structure, and a method for sensing a chemical substance.
Patent Rotary blood pump and control system thereforTansley, Geoffrey; Ayre, Peter; Watterson, Peter Andrew; Woodard, John; Ventrassist Pty Ltd; University of Technology (2015)A pump assembly and estimation and control system therefor, the pump adapted for continuous flow pumping of blood. In a particular form, the pump is a centrifugal pump wherein the impeller is entirely sealed within the pump housing and is exclusively hydrodynamically suspended therein against movement in three translational and two rotational degrees of freedom as the impeller rotates within the fluid urged by electromagnetic means external to the pump cavity. Hydrodynamic suspension is assisted by the impeller having deformities therein such as blades with surfaces tapered from the leading edges to the trailing edges of bottom and top surfaces thereof.
Patent Blood Pump Systems and MethodsTansley, Geoffrey; Franano, Nicholas; Loree, Howard; Woodard, Stephen; Hutto, Barrat (2017)The present invention relates to a rotary blood pump with a double pivot contact bearing system with an operating range between about 50 mL/min and about 1500 mL/min, wherein the force on the upper bearing is less than 3 N during operating speeds up to 6000 rpm. The rotary blood pump is part of a blood pump system that includes blood conduit(s), a control system with optional sensors, and a power source. Embodiments of the present invention may include elements designed to increase the length of time the rotary blood system can operate effectively in vivo, including wear resistant bearing materials, a rotor back plate for magnetic attraction of the rotor to reduce bearing pivot bearing forces and wear, a rotor size and shape and a bearing gap that combine to create a hydrodynamic bearing effect and reduce bearing pivot bearing forces and wear, improved intravascular conduits with increased resistance to thrombosis, conduit insertion site cuffs to resist infection, and conduit side ports amenable to the easy insertion of guidewire and catheter-based medical devices to treat conduits and related blood vessels to maintain blood pump system function over time.