• Non-surgical osteoarthritis therapy, intra-articular drug delivery towards clinical applications 

  Liang, Yujie; Xu, Xiao; Xu, Limei; Prasadam, Indira; Duan, Li; Xiao, Yin; Xia, Jiang (Journal of Drug Targeting, 2020)

  Osteoarthritis (OA）is a common orthopaedic disease in middle-aged and aged people. To date, no disease-modifying drug is available to prevent the progression of OA. Surgical treatment of OA has complications such as pain ...

  JOURNAL ARTICLE

• Human β-defensin 3 gene modification promotes the osteogenic differentiation of human periodontal ligament cells and bone repair in periodontitis 

  Li, Lingjun; Jiang, Han; Chen, Rixin; Zhou, Jing; Xiao, Yin; Zhang, Yangheng; Yan, Fuhua (International Journal of Oral Science, 2020)

  Efforts to control inflammation and achieve better tissue repair in the treatment of periodontitis have been ongoing for years. Human β-defensin 3, a broad-spectrum antimicrobial peptide has been proven to have a variety ...

  JOURNAL ARTICLE

• The Development of Extracellular Vesicle-Integrated Biomaterials for Bone Regeneration 

  Zhou, Yinghong; Xiao, Yin (Biomimicked Biomaterials: Advances in Tissue Engineering and Regenerative Medicine, 2020)

  The clinical need for effective bone regeneration remains in huge demands. Although autologous and allogeneic bone grafts are generally considered “gold standard” treatments for bone defects, these approaches may result ...

  BOOK CHAPTER

• Lithium silicate-based bioceramics promoting chondrocyte maturation by immunomodulating M2 macrophage polarization 

  Zhai, Dong; Chen, Lei; Chen, Yu; Zhu, Yufang; Xiao, Yin; Wu, Chengtie (Biomaterials Science, 2020)

  Articular cartilage lesions occur frequently but unfortunately the damaged cartilage has a very limited intrinsic repair capacity. Since the cartilage damage can cause sterile inflammation, the effects of inflammation on ...

  JOURNAL ARTICLE

• 3D printing of metal-organic framework nanosheets-structured scaffolds with tumor therapy and bone construction 

  Dang, Wentao; Ma, Bing; Li, Bo; Huan, Zhiguang; Ma, Nan; Zhu, Haibo; Chang, Jiang; Xiao, Yin; Wu, Chengtie (Biofabrication, 2020)

  After surgical resection for a bone tumor, the uncleared bone tumor cells can multiply and cause recurrence of the bone tumor. It is worthwhile to design a scaffold that kills the remaining bone tumor cells and repairs ...

  JOURNAL ARTICLE

• Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment 

  Duan, Li; Liang, Yujie; Xu, Xiao; Xiao, Yin; Wang, Daping (Arthritis Research & Therapy, 2020)

  Cartilage matrix remodelling homeostasis is a crucial factor in maintaining cartilage integrity. Loss of cartilage integrity is a typical characteristic of osteoarthritis (OA). Strategies aimed at maintaining cartilage ...

  JOURNAL ARTICLE

• Multi-faceted effects of mesenchymal stem cells (MSCs) determined by immune microenvironment and their implications on MSC/biomaterial-based inflammatory disease therapy 

  Chen, Lingling; Liu, Guanqi; Wu, Jinyan; Zhou, Xuan; Zhao, Yiming; Chen, Zetao; Lin, Zhengmei; Xiao, Yin (Applied Materials Today, 2020)

  Inflammatory diseases result in destructive events, leading to tissue loss and functional impairment. Due to their anti-inflammatory effect and direct effect in tissue repair, mesenchymal stem cells (MSCs) are often exploited ...

  JOURNAL ARTICLE

• Dose controlled nitric oxide-based strategies for antibacterial property in biomedical devices 

  Mendhi, Jayanti; Asgari, Mohammad; Ratheesh, Greeshma; Prasadam, Indira; Yang, Ying; Xiao, Yin (Applied Materials Today, 2020)

  Infections caused by bacterial adhesion and biofilms are a significant health and economic problem, resulting in considerable patient morbidity and mortality. Nitric oxide (NO), a small molecule and free radical, is known ...

  JOURNAL ARTICLE

• Bioactivation of Encapsulation Membranes Reduces Fibrosis and Enhances Cell Survival 

  Tan, Richard P; Hallahan, Nicole; Kosobrodova, Elena; Michael, Praveesuda L; Wei, Fei; Santos, Miguel; Lam, Yuen Ting; Chan, Alex HP; Xiao, Yin; Bilek, Marcela MM; Thorn, Peter; Wise, Steven G (ACS Applied Materials & Interfaces, 2020)

  Encapsulation devices are an emerging barrier technology designed to prevent the immunorejection of replacement cells in regenerative therapies for intractable diseases. However, traditional polymers used in current devices ...

  JOURNAL ARTICLE

• Dihydrolipoic Acid-Gold Nanoclusters Regulate Microglial Polarization and Have the Potential To Alter Neurogenesis 

  Xiao, Lan; Wei, Fei; Zhou, Yinghong; Anderson, Gregory J; Frazer, David M; Lim, Yi Chieh; Liu, Tianqing; Xiao, Yin (Nano Letters, 2020)

  Microglia-mediated neuroinflammation is one of the most significant features in a variety of central nervous system (CNS) disorders such as traumatic brain injury, stroke, and many neurodegenerative diseases. Microglia ...

  JOURNAL ARTICLE

• Fe3O4@TiO2-Laden Neutrophils Activate Innate Immunity via Photosensitive Reactive Oxygen Species Release 

  Zhang, Peng; Zhao, Qin; Shi, Miusi; Yin, Chengcheng; Zhao, Zifan; Shen, Kailun; Qiu, Yun; Xiao, Yin; Zhao, Yanbing; Yang, Xiangliang; Zhang, Yufeng (Nano Letters, 2020)

  Although a variety of advanced sterilization materials and treatments have emerged, the complete elimination of bacterial infection, especially drug-resistant bacterial infection, remains an immense challenge. Here, we ...

  JOURNAL ARTICLE

• Patient-Specific Bone Particles Bioprinting for Bone Tissue Engineering 

  Ratheesh, Greeshma; Vaquette, Cedryck; Xiao, Yin (Advanced Healthcare Materials, 2020)

  Although bioinks with both high printability and shape fidelity while maintaining high cell viability are developed, the biofunctionality of the resulting bioprinted construct is often overlooked. To address this, a ...

  JOURNAL ARTICLE

• Biomaterials Regulating Bone Hematoma for Osteogenesis 

  Yang, Ying; Xiao, Yin (Advanced Healthcare Materials, 2020)

  Blood coagulation in tissue healing not only prevents blood loss, but also forms a natural scaffold for tissue repair and regeneration. As blood clot formation is the initial and foremost phase upon bone injury, and the ...

  JOURNAL ARTICLE

• Immunomodulation-Based Strategy for Improving Soft Tissue and Metal Implant Integration and Its Implications in the Development of Metal Soft Tissue Materials 

  Liu, Runheng; Chen, Shoucheng; Huang, Peina; Liu, Guanqi; Luo, Pu; Li, Zhipeng; Xiao, Yin; Chen, Zhuofan; Chen, Zetao (Advanced Functional Materials, 2020)

  The difficulties associated with metal implants and soft tissue integration have significantly affected the applications of metal implants in soft-tissue-related areas. Prompted by the close association between soft tissue ...

  JOURNAL ARTICLE

• Autologous Versatile Vesicles-Incorporated Biomimetic Extracellular Matrix Induces Biomineralization 

  Wei, Yan; Shi, Miusi; Zhang, Jinglun; Zhang, Xiaoxin; Shen, Kailun; Wang, Rui; Miron, Richard J; Xiao, Yin; Zhang, Yufeng (Advanced Functional Materials, 2020)

  Restoring extracellular matrix (ECM) with supportive and osteoinductive abilities is of great significance for bone tissue regeneration. Current approaches involving cell-based scaffolds or nanoparticle-modified biomimic-ECM ...

  JOURNAL ARTICLE

• Do Vestibular Physiotherapy and a Clinical Pathway in the Emergency Department Improve Management of Vertigo? 

  Stewart, V; Rosbergen, I; Tsang, B; Hoffman, A; Kwan, S; Grimley, R (OTO Open, 2022)

  Objective: Determine the effects of a vertigo/dizziness emergency department (ED) clinical pathway incorporating vestibular physiotherapy on quality and efficiency of care. Study Design: A multisite retrospective study ...

  JOURNAL ARTICLE

• Exploring dimensions of quality-of-life in survivors of stroke with communication disabilities - a brief report 

  Thayabaranathan, T; Baker, C; Andrew, NE; Stolwyk, R; Thrift, AG; Carter, H; Moss, K; Kim, J; Wallace, SJ; Brogan, E; Grimley, R; Lannin, NA; Rose, ML; Cadilhac, DA (Topics in Stroke Rehabilitation, 2022)

  Background: People with communication disabilities post-stroke have poor quality-of-life. Objectives: We aimed to explore the association of self-reported communication disabilities with different dimensions of quality-of-life ...

  JOURNAL ARTICLE

• The implementation of medical revalidation: An assessment using normalisation process theory 

  Tazzyman, A; Ferguson, J; Hillier, C; Boyd, A; Tredinnick-Rowe, J; Archer, J; De Bere, SR; Walshe, K (BMC Health Services Research, 2017)

  Background: Medical revalidation is the process by which all licensed doctors are legally required to demonstrate that they are up to date and fit to practise in order to maintain their licence. Revalidation was introduced ...

  JOURNAL ARTICLE

• Remediating doctors' performance to restore patient safety: A realist review protocol 

  Price, T; Brennan, N; Cleland, J; Prescott-Clements, L; Wanner, A; Withers, L; Wong, G; Archer, J (BMJ Open, 2018)

  Introduction Underperformance by doctors poses a risk to patient safety. Remediation is an intervention designed to remedy underperformance and return a doctor to safe practice. Remediation is widely used across healthcare ...

  JOURNAL ARTICLE

• Validation of multisource feedback in assessing medical performance: A systematic review 

  Stevens, S; Read, J; Baines, R; Chatterjee, A; Archer, J (Journal of Continuing Education in the Health Professions, 2018)

  Introduction: Over the past 10 years, a number of systematic reviews have evaluated the validity of multisource feedback (MSF) to assess and quality-assure medical practice. The purpose of this study is to synthesize the ...

  JOURNAL ARTICLE

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