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dc.contributor.authorHambly, Jessica L
dc.contributor.authorKhan, Sohil
dc.contributor.authorMcDermott, Brett
dc.contributor.authorBor, William
dc.contributor.authorHaywood, Alison
dc.date.accessioned2018-10-31T06:38:32Z
dc.date.available2018-10-31T06:38:32Z
dc.date.issued2016
dc.identifier.issn0269-8811
dc.identifier.doi10.1177/0269881116658985
dc.identifier.urihttp://hdl.handle.net/10072/100035
dc.description.abstractThere is a critical need for evaluation of the pharmacotherapies used in conduct disorder (CD), due to the high incidence of off-label prescribing. The aim of this review was to identify concerns associated with the safety, efficacy and impact on quality of life (QOL) that pharmacotherapy has in children and adolescents with CD. A systematic review was undertaken using pre-defined search criteria and four databases, including reference searches. We assessed these studies using the Strength of Recommendation Taxonomy, Grading of Recommendations Assessment, Development and Evaluation, and Review Manager Risk of Bias (RevMan®) tools. There were 12 randomised controlled trials that met our inclusion criteria. Studies included: antipsychotics, atomoxetine, lithium, clonidine, divalproex sodium and psychostimulants. The antipsychotics demonstrated efficacy, but were associated with adverse effects. Other agents demonstrated mixed responses, highlighting the lack of clinical significance and increased incidence of adverse effects. The management of related adverse effects was addressed to assist with clinical gaps. Overall, there is limited evidence regarding the role of pharmacotherapy in CD. More research is needed that takes into account the heterogeneity of CD and analysis of pharmacotherapy in pure CD.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSage Publications
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto9
dc.relation.ispartofjournalJournal of Psychopharmacology
dc.subject.fieldofresearchClinical Pharmacology and Therapeutics
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchPsychology and Cognitive Sciences
dc.subject.fieldofresearchcode111502
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode17
dc.titlePharmacotherapy of conduct disorder: Challenges, options and future directions
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Pharmacy
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorHaywood, Alison
gro.griffith.authorHambly, Jessica L.
gro.griffith.authorKhan, Sohil A.


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