• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis

    Thumbnail
    View/Open
    BrenuPUB2036.pdf (260.6Kb)
    File version
    Version of Record (VoR)
    Author(s)
    Brenu, Ekua W
    Broadley, Simon
    Thao, Nguyen
    Johnston, Samantha
    Ramos, Sandra
    Staines, Don
    Marshall-Gradisnik, Sonya
    Griffith University Author(s)
    Staines, Don R.
    Broadley, Simon
    Ramos, Sandra B.
    Marshall-Gradisnik, Sonya M.
    Johnston, Samantha
    Brenu, Ekua
    Nguyen, Thao
    Year published
    2016
    Metadata
    Show full item record
    Abstract
    Background. CD8+ T cells have putative roles in the regulation of adaptive immune responses during infection.The purpose of this paper is to compare the status ofCD8+ T cells inMultiple Sclerosis (MS) andChronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). Methods.This preliminary investigation comprised 23 CFS/ME patients, 11 untreated MS patients, and 30 nonfatigued controls. Whole blood samples were collected from participants, stained with monoclonal antibodies, and analysed on the flow cytometer. Using the following CD markers, CD27 and CD45RA (CD45 exon isoform 4), CD8+ T cells were divided into na¨ıve, central ...
    View more >
    Background. CD8+ T cells have putative roles in the regulation of adaptive immune responses during infection.The purpose of this paper is to compare the status ofCD8+ T cells inMultiple Sclerosis (MS) andChronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). Methods.This preliminary investigation comprised 23 CFS/ME patients, 11 untreated MS patients, and 30 nonfatigued controls. Whole blood samples were collected from participants, stained with monoclonal antibodies, and analysed on the flow cytometer. Using the following CD markers, CD27 and CD45RA (CD45 exon isoform 4), CD8+ T cells were divided into na¨ıve, central memory (CM), effector memory CD45RA− (EM), and effector memory CD45RA+ (EMRA) cells. Results. Surface expressions of BTLA, CD127, and CD49/CD29 were increased on subsets of CD8+ T cells fromMS patients. In the CFS/ME patients CD127was significantly decreased on all subsets ofCD8+Tcells in comparison to the nonfatigued controls. PSGL-1was significantly reduced in the CFS/ME patients in comparison to the nonfatigued controls. Conclusions.The results suggest significant deficits in the expression of receptors and adhesion molecules on subsets of CD8+ T cells in both MS and CFS/ME patients. These deficits reported may contribute to the pathogenesis of these diseases. However, larger sample size is warranted to confirm and support these encouraging preliminary findings.
    View less >
    Journal Title
    Journal of Immunology Research
    DOI
    https://doi.org/10.1155/2016/9064529
    Copyright Statement
    © 2016 EkuaW. Brenu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Immunology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/100161
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander