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dc.contributor.authorWang, Dongdong
dc.contributor.authorFeng, Yunjiang
dc.contributor.authorMurtaza, Mariyam
dc.contributor.authorWood, Stephen
dc.contributor.authorMellick, George
dc.contributor.authorHooper, John NA
dc.contributor.authorQuinn, Ronald J
dc.date.accessioned2017-11-28T04:06:15Z
dc.date.available2017-11-28T04:06:15Z
dc.date.issued2016
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/acs.jnatprod.5b00987
dc.identifier.urihttp://hdl.handle.net/10072/100178
dc.description.abstractA grand challenge in natural product chemistry is to determine the biological effects of all natural products. A phenotypic approach is frequently used for determining the activity of a compound and its potential impact on a disease state. Chemical investigation of a specimen of Jaspis splendens collected from the Great Barrier Reef resulted in the isolation of a new pterin derivative, jaspterin (1), a new bisindole alkaloid, splendamide (2), and a new imidazole alkaloid, jaspnin A (3) TFA salt. Jaspamycin (8) and 6-bromo-1H-indole-3-carboximidamide (16) are reported for the first time as naturally occurring metabolites. Known nucleosides (4–7, 9, 10), aglycones (11–13), indole alkaloids (14, 15, 17), and jaspamide peptides (18–22) were also isolated. The structures of the three new compounds 1–3 were unambiguously elucidated based on NMR and mass spectroscopic data. Jaspnin A (3) contained a rare thiomethylated imidazolinium unit. Coupling an unbiased phenotypic assay using a human olfactory neurosphere-derived cell model of Parkinson’s disease to all of the natural products from the species J. splendens allowed the phenotypic profiles of the metabolites to be investigated.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofpagefrom353
dc.relation.ispartofpageto361
dc.relation.ispartofissue2
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume79
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.titleA Grand Challenge: Unbiased Phenotypic Function of Metabolites from Jaspis splendens against Parkinson's Disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.rights.copyright© 2016 The American Chemical Society and American Society of Pharmacognosy. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
gro.hasfulltextFull Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorMellick, George
gro.griffith.authorFeng, Yun J.
gro.griffith.authorWood, Stephen A.
gro.griffith.authorWang, Dongdong
gro.griffith.authorMurtaza, Mariyam
gro.griffith.authorHooper, John N.


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