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dc.contributor.authorBellapart, Judith
dc.contributor.authorAbi-Fares, Catherine
dc.contributor.authorCuthbertson, Kylie
dc.contributor.authorDunster, Kimble
dc.contributor.authorDiab, Sara
dc.contributor.authorPlatts, David G
dc.contributor.authorRaffell, Christopher
dc.contributor.authorGabrielian, Levon
dc.contributor.authorBarnett, Adrian
dc.contributor.authorParatz, Jennifer
dc.contributor.authorBoots, Rob
dc.contributor.authorFraser, John F
dc.date.accessioned2018-08-28T04:46:17Z
dc.date.available2018-08-28T04:46:17Z
dc.date.issued2016
dc.identifier.issn0269-9052
dc.identifier.doi10.1080/02699052.2016.1199894
dc.identifier.urihttp://hdl.handle.net/10072/100232
dc.description.abstractBackground: Cerebral microcirculation after head injury is heterogeneous and temporally variable. Regions at risk of infarction such as peri-contusional areas are vulnerable to anaemia. However, direct quantification of the cerebral microcirculation is clinically not feasible. This study describes a novel experimental head injury model correlating cerebral microcirculation with histopathology analysis. Objective: To test the hypothesis that cerebral microcirculation at the ischaemic penumbrae is reduced over time when compared with non-injured regions. Methods: Merino sheep were instrumented using a transeptal catheter to inject coded microspheres into the left cardiac atrium, ensuring systemic distribution. After a blunt impact over the left parietal region, cytometric analyses quantified cerebral microcirculation and amyloid precursor protein staining identified axonal injury in pre-defined anatomical regions. A mixed effect regression model assessed the hourly blood flow results during 4 hours after injury. Results: Cerebral microcirculation showed temporal reductions with minimal amyloid staining except for the ipsilateral thalamus and medulla. Conclusion: The spatial heterogeneity and temporal reduction of cerebral microcirculation in ovine models occur early, even after mild head injury, independent of the intracranial pressure and the level of haemoglobin. Alternate approaches to ensure recovery of regions with reversible injury require a targeted assessment of cerebral microcirculation.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherTaylor & Francis
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto10
dc.relation.ispartofjournalBrain Injury
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode52
dc.titleCerebral microcirculation during mild head injury after a contusion and acceleration experimental model in sheep
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2016 Taylor & Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in Brain Injury on Volume 30, 2016 - Issue 13-14, Pages 1542-1551, 2016, available online: https://www.tandfonline.com/doi/10.1080/02699052.2016.1199894
gro.hasfulltextFull Text
gro.griffith.authorParatz, Jenny D.
gro.griffith.authorFraser, John F.


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