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dc.contributor.authorMovva, Ramya
dc.contributor.authorLobb, Michael
dc.contributor.authorCuiv, Paraic O
dc.contributor.authorFlorin, Timothy Fij
dc.contributor.authorDuley, John A
dc.contributor.authorOancea, Iulia
dc.date.accessioned2018-10-30T05:46:25Z
dc.date.available2018-10-30T05:46:25Z
dc.date.issued2016
dc.identifier.issn0167-7012
dc.identifier.doi10.1016/j.mimet.2016.07.017
dc.identifier.urihttp://hdl.handle.net/10072/100262
dc.description.abstractThiopurines are anti-inflammatory prodrugs. We hypothesised that bacteria may contribute to conversion to active drug. Escherichia coli strain DH5α was evaluated to determine whether it could metabolise the thiopurine drugs, thioguanine or mercaptopurine, to thioguanine nucleotides. A rapid and reliable high performance liquid chromatography (ultraviolet detection) method was developed to quantify indirectly thioguanine nucleotides, by measuring thioguanine nucleoside.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom102
dc.relation.ispartofpageto107
dc.relation.ispartofjournalJournal of Microbiological Methods
dc.relation.ispartofvolume128
dc.subject.fieldofresearchMicrobiology not elsewhere classified
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchMedical Microbiology
dc.subject.fieldofresearchcode060599
dc.subject.fieldofresearchcode0605
dc.subject.fieldofresearchcode1108
dc.titleMicrobial metabolism of thiopurines: A method to measure thioguanine nucleotides
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Pharmacy
gro.hasfulltextNo Full Text
gro.griffith.authorMovva, Ramya


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