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  • LAT Transport Inhibitors from Pittosporum venulosum Identified by NMR Fingerprint Analysis

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    Author(s)
    Grkovic, Tanja
    Pouwer, Rebecca H
    Wang, Qian
    Guymer, Gordon P
    Holst, Jeff
    Quinn, Ronald J
    Griffith University Author(s)
    Quinn, Ronald J.
    Year published
    2015
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    Abstract
    1H NMR fingerprints were used as the guiding principle for the isolation of minor compounds related to the l-type amino acid transporter inhibitors venulosides A (1) and B (2). Two new monoterpene glycosides, namely, venulosides C (3) and D (4), were isolated from a Queensland collection of the plant Pittosporum venulosum. Compounds 3 and 4 were found to inhibit l-leucine transport in LNCaP cells with IC50 values of 11.47 and 39.73 μM, respectively. The venulosides are the first reported natural product inhibitors of leucine transport in prostate cancer cells, and the isolation of the minor compounds provides some early SAR ...
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    1H NMR fingerprints were used as the guiding principle for the isolation of minor compounds related to the l-type amino acid transporter inhibitors venulosides A (1) and B (2). Two new monoterpene glycosides, namely, venulosides C (3) and D (4), were isolated from a Queensland collection of the plant Pittosporum venulosum. Compounds 3 and 4 were found to inhibit l-leucine transport in LNCaP cells with IC50 values of 11.47 and 39.73 μM, respectively. The venulosides are the first reported natural product inhibitors of leucine transport in prostate cancer cells, and the isolation of the minor compounds provides some early SAR information.
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    Journal Title
    Journal of Natural Products
    Volume
    78
    Issue
    6
    DOI
    https://doi.org/10.1021/np500968t
    Copyright Statement
    © 2015 The American Chemical Society and American Society of Pharmacognosy. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
    Subject
    Chemical sciences
    Biological sciences
    Other biological sciences not elsewhere classified
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/100264
    Collection
    • Journal articles

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