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dc.contributor.authorMujumdar, Prashant
dc.contributor.authorPoulsen, Sally-Ann
dc.date.accessioned2017-11-28T01:42:16Z
dc.date.available2017-11-28T01:42:16Z
dc.date.issued2015
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/np501015m
dc.identifier.urihttp://hdl.handle.net/10072/100275
dc.description.abstractPrimary sulfonamide and primary sulfamate functional groups feature prominently in the structures of U.S. FDA-approved drugs. However, the natural product chemical space contains few examples of these well-known zinc-binding chemotypes, with just two primary sulfonamide and five primary sulfamate natural products isolated and characterized to date. One of these natural products was isolated from a marine sponge, with the remainder isolated from Streptomyces species. In this review are outlined for the first time the discovery, isolation, striking breadth of bioactivity, and total synthesis (where available) for this rare group of natural products.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofpagefrom1470
dc.relation.ispartofpageto1477
dc.relation.ispartofissue6
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume78
dc.subject.fieldofresearchBiological Sciences not elsewhere classified
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode069999
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleNatural Product Primary Sulfonamides and Primary Sulfamates
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorPoulsen, Sally-Ann
gro.griffith.authorMujumdar, Prashant


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