dc.contributor.author | Mallik, Sanchari Basu | |
dc.contributor.author | Mudgal, Jayesh | |
dc.contributor.author | Nampoothiri, Madhavan | |
dc.contributor.author | Hall, Susan | |
dc.contributor.author | Anoopkumar-Dukie, Shailendra | |
dc.contributor.author | Grant, Gary | |
dc.contributor.author | Rao, C Mallikarjuna | |
dc.contributor.author | Arora, Devinder | |
dc.date.accessioned | 2018-01-04T02:32:50Z | |
dc.date.available | 2018-01-04T02:32:50Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0304-3940 | |
dc.identifier.doi | 10.1016/j.neulet.2016.08.044 | |
dc.identifier.uri | http://hdl.handle.net/10072/100310 | |
dc.description.abstract | Accumulating data links inflammation, oxidative stress and immune system in the pathophysiology of major depressive disorders. Sickness behaviour is a set of behavioural changes that develop during infection, eventually leading to decrease in mobility and depressed behaviour. Lipopolysaccharide (LPS) induces a depression-like state in animals that mimics sickness behaviour. Caffeic acid, a naturally occurring polyphenol, possesses antioxidant and anti-inflammatory properties. The present study was designed to explore the potential of caffeic acid against LPS-induced sickness behaviour in mice. Caffeic acid (30 mg/kg) and imipramine (15 mg/kg) were administered orally one hour prior to LPS (1.5 mg/kg) challenge. Behavioural assessment was carried out between 1 and 2 h and blood samples were collected at 3 h post-LPS injection. Additionally, cytokines (brain and serum) and brain oxidative stress markers were estimated. LPS increased the systemic and brain cytokine levels, altered the anti-oxidant defence and produced key signs of sickness behaviour in animals. Caffeic acid treatment significantly reduced the LPS-induced changes, including reduced expression of inflammatory markers in serum and whole brain. Caffeic acid also exerted an anti-oxidant effect, which was evident from the decreased levels of oxidative stress markers in whole brain. Our data suggests that caffeic acid can prevent the neuroinflammation-induced acute and probably the long term neurodegenerative changes. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 218 | |
dc.relation.ispartofpageto | 223 | |
dc.relation.ispartofjournal | Neuroscience Letters | |
dc.relation.ispartofvolume | 632 | |
dc.subject.fieldofresearch | Neurosciences | |
dc.subject.fieldofresearch | Neurosciences not elsewhere classified | |
dc.subject.fieldofresearch | Psychology | |
dc.subject.fieldofresearch | Cognitive and computational psychology | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearch | Biological psychology | |
dc.subject.fieldofresearchcode | 3209 | |
dc.subject.fieldofresearchcode | 320999 | |
dc.subject.fieldofresearchcode | 52 | |
dc.subject.fieldofresearchcode | 5204 | |
dc.subject.fieldofresearchcode | 3101 | |
dc.subject.fieldofresearchcode | 5202 | |
dc.title | Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Hall, Susan | |
gro.griffith.author | Grant, Gary D. | |
gro.griffith.author | Anoopkumar-Dukie, Shailendra | |
gro.griffith.author | Arora, Devinder S. | |