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dc.contributor.authorMallik, Sanchari Basu
dc.contributor.authorMudgal, Jayesh
dc.contributor.authorNampoothiri, Madhavan
dc.contributor.authorHall, Susan
dc.contributor.authorAnoopkumar-Dukie, Shailendra
dc.contributor.authorGrant, Gary
dc.contributor.authorRao, C Mallikarjuna
dc.contributor.authorArora, Devinder
dc.date.accessioned2018-01-04T02:32:50Z
dc.date.available2018-01-04T02:32:50Z
dc.date.issued2016
dc.identifier.issn0304-3940
dc.identifier.doi10.1016/j.neulet.2016.08.044
dc.identifier.urihttp://hdl.handle.net/10072/100310
dc.description.abstractAccumulating data links inflammation, oxidative stress and immune system in the pathophysiology of major depressive disorders. Sickness behaviour is a set of behavioural changes that develop during infection, eventually leading to decrease in mobility and depressed behaviour. Lipopolysaccharide (LPS) induces a depression-like state in animals that mimics sickness behaviour. Caffeic acid, a naturally occurring polyphenol, possesses antioxidant and anti-inflammatory properties. The present study was designed to explore the potential of caffeic acid against LPS-induced sickness behaviour in mice. Caffeic acid (30 mg/kg) and imipramine (15 mg/kg) were administered orally one hour prior to LPS (1.5 mg/kg) challenge. Behavioural assessment was carried out between 1 and 2 h and blood samples were collected at 3 h post-LPS injection. Additionally, cytokines (brain and serum) and brain oxidative stress markers were estimated. LPS increased the systemic and brain cytokine levels, altered the anti-oxidant defence and produced key signs of sickness behaviour in animals. Caffeic acid treatment significantly reduced the LPS-induced changes, including reduced expression of inflammatory markers in serum and whole brain. Caffeic acid also exerted an anti-oxidant effect, which was evident from the decreased levels of oxidative stress markers in whole brain. Our data suggests that caffeic acid can prevent the neuroinflammation-induced acute and probably the long term neurodegenerative changes.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom218
dc.relation.ispartofpageto223
dc.relation.ispartofjournalNeuroscience Letters
dc.relation.ispartofvolume632
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchBiological psychology
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode320999
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode5204
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode5202
dc.titleCaffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorHall, Susan
gro.griffith.authorGrant, Gary D.
gro.griffith.authorAnoopkumar-Dukie, Shailendra
gro.griffith.authorArora, Devinder S.


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