Show simple item record

dc.contributor.authorNikles, Jane
dc.contributor.authorMitchell, Geoffrey K
dc.contributor.authorHardy, Janet
dc.contributor.authorSenior, Hugh
dc.contributor.authorCarmont, Sue-Ann
dc.contributor.authorSchluter, Philip J
dc.contributor.authorVora, Rohan
dc.contributor.authorCurrow, David
dc.contributor.authorYelland, Michael
dc.date.accessioned2019-03-11T01:19:27Z
dc.date.available2019-03-11T01:19:27Z
dc.date.issued2016
dc.identifier.issn0269-2163
dc.identifier.doi10.1177/0269216316635012
dc.identifier.urihttp://hdl.handle.net/10072/100321
dc.description.abstractBackground and rationale: Chronic pain is the most feared symptom in palliative care (PC) patients. While paracetamol is effective for mild to moderate pain and useful when used in combination with “weak opioids,” it is not certain that there is sufficient continuing benefit when used in conjunction with “strong” opioids for moderate to severe pain to justify the additional medication burden. Although there have been several studies describing opioid-sparing effects of paracetamol, there have been only a handful in patients with advanced cancer and pain despite strong opioids. A 2013 critical review concluded that the role of paracetamol in management of cancer pain remains controversial.1 We conducted a series of n-of-1 trials to test the feasibility of using this methodology to obtain the per patient effectiveness of paracetamol in providing additional analgesia to regular opioids in people with advanced cancer experiencing moderate to severe pain.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherSage Publications
dc.relation.ispartofpagefrom800
dc.relation.ispartofpageto802
dc.relation.ispartofissue8
dc.relation.ispartofjournalPalliative Medicine
dc.relation.ispartofvolume30
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchOther Medical and Health Sciences
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode1117
dc.subject.fieldofresearchcode1199
dc.titleSingle-patient multiple crossover studies to determine the effectiveness of paracetamol in relieving pain suffered by patients with advanced cancer taking regular opioids: A pilot study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionPost-print
gro.rights.copyrightNikles, Jane et al, Single-patient multiple crossover studies to determine the effectiveness of paracetamol in relieving pain suffered by patients with advanced cancer taking regular opioids: A pilot study, Palliative Medicine, March 1, 2016. Copyright 2016 The Authors. Reprinted by permission of SAGE Publications.
gro.hasfulltextFull Text
gro.griffith.authorYelland, Michael


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record