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  • Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells

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    Author(s)
    Fang, Wen-Hui
    Kumar, Shant
    McDowell, Garry
    Smith, David
    Krupinski, Jurek
    Olah, Peter
    Al-Baradie, Raid Saleem
    Al-Rukban, Mohammad Othman
    Petcu, Eugene Bogdan
    Slevin, Mark
    Griffith University Author(s)
    Petcu, Eugen B.
    Year published
    2016
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    Abstract
    The potential use of stem cells as therapeutics in disease has gained momentum over the last few years and recently phase-I clinical trials have shown favourable results in treatment of a small cohort of acute stroke patients. Similarly, they have been used in preclinical models drug-loaded for the effective treatment of solid tumours. Here we have characterized uptake and release of a novel p5-cyclin-dependent kinase 5 (CDK5) inhibitory peptide by mesenchymal stem cells and showed release levels capable of blocking aberrant cyclin-dependent kinase 5 (CDK5) signaling pathways, through phosphorylation of cyclin-dependent ...
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    The potential use of stem cells as therapeutics in disease has gained momentum over the last few years and recently phase-I clinical trials have shown favourable results in treatment of a small cohort of acute stroke patients. Similarly, they have been used in preclinical models drug-loaded for the effective treatment of solid tumours. Here we have characterized uptake and release of a novel p5-cyclin-dependent kinase 5 (CDK5) inhibitory peptide by mesenchymal stem cells and showed release levels capable of blocking aberrant cyclin-dependent kinase 5 (CDK5) signaling pathways, through phosphorylation of cyclin-dependent kinase 5 (CDK5) and p53. These pathways represent the major acute mechanism stimulating apoptosis after stroke and hence its modulation could benefit patient recovery. This work indicates a potential use for drug-loaded stem cells as delivery vehicles for stroke therapeutics and in addition as anticancer receptacles particularly, if a targeting and/or holding mechanism can be defined.
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    Journal Title
    Stem Cells International
    Volume
    2016
    DOI
    https://doi.org/10.1155/2016/2165462
    Copyright Statement
    © 2016 Wen-Hui Fang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Biochemistry and cell biology
    Biochemistry and cell biology not elsewhere classified
    Clinical sciences
    Publication URI
    http://hdl.handle.net/10072/100360
    Collection
    • Journal articles

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