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dc.contributor.authorFang, Wen-Hui
dc.contributor.authorKumar, Shant
dc.contributor.authorMcDowell, Garry
dc.contributor.authorSmith, David
dc.contributor.authorKrupinski, Jurek
dc.contributor.authorOlah, Peter
dc.contributor.authorAl-Baradie, Raid Saleem
dc.contributor.authorAl-Rukban, Mohammad Othman
dc.contributor.authorPetcu, Eugene Bogdan
dc.contributor.authorSlevin, Mark
dc.date.accessioned2017-07-26T00:25:38Z
dc.date.available2017-07-26T00:25:38Z
dc.date.issued2016
dc.identifier.issn1687-966X
dc.identifier.doi10.1155/2016/2165462
dc.identifier.urihttp://hdl.handle.net/10072/100360
dc.description.abstractThe potential use of stem cells as therapeutics in disease has gained momentum over the last few years and recently phase-I clinical trials have shown favourable results in treatment of a small cohort of acute stroke patients. Similarly, they have been used in preclinical models drug-loaded for the effective treatment of solid tumours. Here we have characterized uptake and release of a novel p5-cyclin-dependent kinase 5 (CDK5) inhibitory peptide by mesenchymal stem cells and showed release levels capable of blocking aberrant cyclin-dependent kinase 5 (CDK5) signaling pathways, through phosphorylation of cyclin-dependent kinase 5 (CDK5) and p53. These pathways represent the major acute mechanism stimulating apoptosis after stroke and hence its modulation could benefit patient recovery. This work indicates a potential use for drug-loaded stem cells as delivery vehicles for stroke therapeutics and in addition as anticancer receptacles particularly, if a targeting and/or holding mechanism can be defined.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherHindawi Publishing
dc.relation.ispartofpagefrom2165462-1
dc.relation.ispartofpageto2165462-10
dc.relation.ispartofjournalStem Cells International
dc.relation.ispartofvolume2016
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchBiochemistry and cell biology not elsewhere classified
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode310199
dc.subject.fieldofresearchcode3202
dc.titleMesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2016 Wen-Hui Fang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorPetcu, Eugen B.


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