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  • Memory-enhancing effect of Rhodiola rosea L extract on aged mice

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    CaoPUB2223.pdf (279.3Kb)
    Author(s)
    Cao, Yanjing
    Liang, Lizhen
    Xu, Jian
    Wu, Jiali
    Yan, Yongxing
    Lin, Ping
    Chen, Qiang
    Zheng, Fengming
    Wang, Qin
    Ren, Qian
    Gou, Zengmei
    Fan, Yongjun
    Du, Yifeng
    Griffith University Author(s)
    Fan, Yongjun
    Year published
    2016
    Metadata
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    Abstract
    Purpose: The memory-enhancing effects of Rhodiola rosea L. extract (RRLE) on normal aged mice were assessed. Methods: In the open-field test, the effect of RRLE (150 and 300 mg/kg) on mouse locomotive activities was evaluated by investigating the extract’s influence on CAT and AchE activities in the brain tissue of mice. Results: Compared with aged group, high dose of RRLE reduced the total distance (3212.4 ± 123.1 cm, p < 0.05) significantly, increased catalase (CAT) activity (101.4 ± 12.2 U/mg pro, p < 0.05), and inhibited acetyl cholinesterase (AChE) activity (0.94 ± 0.12 U/mg pro, p < 0.05) in the brain tissue of aged ...
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    Purpose: The memory-enhancing effects of Rhodiola rosea L. extract (RRLE) on normal aged mice were assessed. Methods: In the open-field test, the effect of RRLE (150 and 300 mg/kg) on mouse locomotive activities was evaluated by investigating the extract’s influence on CAT and AchE activities in the brain tissue of mice. Results: Compared with aged group, high dose of RRLE reduced the total distance (3212.4 ± 123.1 cm, p < 0.05) significantly, increased catalase (CAT) activity (101.4 ± 12.2 U/mg pro, p < 0.05), and inhibited acetyl cholinesterase (AChE) activity (0.94 ± 0.12 U/mg pro, p < 0.05) in the brain tissue of aged mice. Conclusion: The results show that RRLE improves the memory functions of aged mice probably by increasing CAT activity while decreasing AChE activity.
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    Journal Title
    Tropical Journal of Pharmaceutical Research
    Volume
    15
    Issue
    7
    DOI
    https://doi.org/10.4314/tjpr.v15i7.14
    Copyright Statement
    © 2016 Human Resources Institute of New Zealand. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Pharmacology and Pharmaceutical Sciences not elsewhere classified
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/100369
    Collection
    • Journal articles

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