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dc.contributor.authorTownsend-Payne, Kelly
dc.contributor.authorLadhani, Shamez N
dc.contributor.authorFindlow, Helen
dc.contributor.authorSlack, Mary
dc.contributor.authorBorrow, Ray
dc.date.accessioned2018-05-08T03:30:25Z
dc.date.available2018-05-08T03:30:25Z
dc.date.issued2016
dc.identifier.issn0264-410X
dc.identifier.doi10.1016/j.vaccine.2016.06.033
dc.identifier.urihttp://hdl.handle.net/10072/100370
dc.description.abstractChildren who develop invasive Haemophilus influenzae serotype b (Hib) disease after immunisation with a highly-effective conjugate vaccine are more likely to have been infected with Hib strains possessing multiple copies of the capsulation locus. Using a recently-validated serum bactericidal antibody (SBA) assay, we tested convalescent sera from 127 Hib vaccine failure cases against clinical Hib strains expressing 1–5 copies of the capsulation locus. SBA titres correlated weakly with anti-capsular IgG antibody concentrations and there was no association between SBA geometric mean titres and number of capsulation locus copies. After infection, children with Hib vaccine failure were equally protected against Hib strains with 1–5 copies of the capsulation locus.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom3931
dc.relation.ispartofpageto3934
dc.relation.ispartofissue34
dc.relation.ispartofjournalVaccine
dc.relation.ispartofvolume34
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.titleChildren with Haemophilus influenzae type b (Hib) vaccine failure have long-term bactericidal antibodies against virulent Hib strains with multiple capsular loci
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSlack, Mary P.


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