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  • Progressive Brain Changes in Patients With Chronic Fatigue Syndrome: A Longitudinal MRI Study

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    Author(s)
    Shan, Zack Y
    Kwiatek, Richard
    Burnet, Richard
    Del Fante, Peter
    Staines, Donald R
    Marshall-Gradisnik, Sonya M
    Barnden, Leighton R
    Griffith University Author(s)
    Staines, Donald R.
    Marshall-Gradisnik, Sonya M.
    Year published
    2016
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    Abstract
    Purpose: To examine progressive brain changes associated with chronic fatigue syndrome (CFS). Materials and Methods: We investigated progressive brain changes with longitudinal MRI in 15 CFS and 10 normal controls (NCs) scanned twice 6 years apart on the same 1.5 Tesla (T) scanner. MR images yielded gray matter (GM) volumes, white matter (WM) volumes, and T1- and T2-weighted signal intensities (T1w and T2w). Each participant was characterized with Bell disability scores, and somatic and neurological symptom scores. We tested for differences in longitudinal changes between CFS and NC groups, inter group differences between ...
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    Purpose: To examine progressive brain changes associated with chronic fatigue syndrome (CFS). Materials and Methods: We investigated progressive brain changes with longitudinal MRI in 15 CFS and 10 normal controls (NCs) scanned twice 6 years apart on the same 1.5 Tesla (T) scanner. MR images yielded gray matter (GM) volumes, white matter (WM) volumes, and T1- and T2-weighted signal intensities (T1w and T2w). Each participant was characterized with Bell disability scores, and somatic and neurological symptom scores. We tested for differences in longitudinal changes between CFS and NC groups, inter group differences between pooled CFS and pooled NC populations, and correlations between MRI and symptom scores using voxel based morphometry. The analysis methodologies were first optimized using simulated atrophy. Results: We found a significant decrease in WM volumes in the left inferior fronto-occipital fasciculus (IFOF) in CFS while in NCs it was unchanged (family wise error adjusted cluster level P value, PFWE < 0.05). This longitudinal finding was consolidated by the group comparisons which detected significantly decreased regional WM volumes in adjacent regions (PFWE < 0.05) and decreased GM and blood volumes in contralateral regions (PFWE < 0.05). Moreover, the regional GM and WM volumes and T2w in those areas showed significant correlations with CFS symptom scores (PFWE < 0.05). Conclusion: The results suggested that CFS is associated with IFOF WM deficits which continue to deteriorate at an abnormal rate.
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    Journal Title
    Journal of Magnetic Resonance Imaging
    Volume
    44
    Issue
    5
    DOI
    https://doi.org/10.1002/jmri.25283
    Copyright Statement
    © 2016 The Authors Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
    Subject
    Physical sciences
    Engineering
    Biomedical engineering not elsewhere classified
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/100458
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    • Journal articles

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