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dc.contributor.authorSang, Shaowei
dc.contributor.authorChen, Bin
dc.contributor.authorWu, Haixia
dc.contributor.authorYang, Zhicong
dc.contributor.authorDi, Biao
dc.contributor.authorWang, Lihua
dc.contributor.authorTao, Xiaoyan
dc.contributor.authorLiu, Xiaobo
dc.contributor.authorLiu, Qiyong
dc.date.accessioned2019-03-22T04:17:44Z
dc.date.available2019-03-22T04:17:44Z
dc.date.issued2015
dc.identifier.issn1567-1348
dc.identifier.doi10.1016/j.meegid.2015.03.005
dc.identifier.urihttp://hdl.handle.net/10072/100465
dc.description.abstractDengue virus and its four serotypes (DENV 1–4) infect approximately 390 million people worldwide each year, with most cases in tropical and subtropical regions. Because of repeated introduction of DENV from epidemic regions and suitable weather conditions, many regions have shifted from hypo-endemicity to hyper-endemicity over recent decades. Since the first dengue outbreak in 1978, it is crucial to understand the current situation in China over nearly 40 years. The purpose of the study was to examine whether dengue in China was endemic or not, which is essential for relevant dengue control and prevention strategy implementation in China. The study, combining epidemiological characteristics of dengue from the disease notification system, phylogenetic and phylogeographic analyses, showed that all four serotypes had been detected in Guangzhou, China, which was dominated by DENV 1–2. The Maximum Likelihood tree analytic results showed that the virus detected in Guangzhou localized in different clades, except of virus of 2002 and 2003 clustered together. There existed the mutual introductions between Guangzhou and Southeast Asia. Most of the viruses were imported from Southeast Asia and the sources of outbreaks in Guangzhou mainly originated from Thailand, Indonesia, and the Philippines. The study indicates that dengue in China still remains as an imported disease, with the possibility of localization.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom178
dc.relation.ispartofpageto190
dc.relation.ispartofjournalInfection, Genetics and Evolution
dc.relation.ispartofvolume32
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchGenetics not elsewhere classified
dc.subject.fieldofresearchcode3105
dc.subject.fieldofresearchcode310599
dc.titleDengue is still an imported disease in China: A case study in Guangzhou
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorLiu, Qiyong


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