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dc.contributor.authorChew, R
dc.contributor.authorNigam, S
dc.contributor.authorSivakumaran, P
dc.date.accessioned2019-03-29T00:29:15Z
dc.date.available2019-03-29T00:29:15Z
dc.date.issued2016
dc.identifier.issn0962-7480
dc.identifier.doi10.1093/occmed/kqw049
dc.identifier.urihttp://hdl.handle.net/10072/100506
dc.description.abstractSecondary alveolar proteinosis is a rare lung disease which may be triggered by a variety of inhaled particles. The diagnosis is made by detection of anti-granulocyte-macrophage colony-stimulating factor antibodies in bronchoalveolar lavage fluid, which appears milky white and contains lamellar bodies. Aluminium has been suggested as a possible cause, but there is little evidence in the literature to support this assertion. We report the case of a 46-year-old former boilermaker and boat builder who developed secondary alveolar proteinosis following sustained heavy aluminium exposure. The presence of aluminium was confirmed both by histological examination and metallurgical analysis of a mediastinal lymph node. Despite cessation of exposure to aluminium and treatment with whole-lung lavage which normally results in improvements in both symptoms and lung function, the outcome was poor and novel therapies are now being used for this patient. It may be that the natural history in aluminium-related alveolar proteinosis is different, with the metal playing a mediating role in the disease process. Our case further supports the link between aluminium and secondary alveolar proteinosis and highlights the need for measures to prevent excessive aluminium inhalation in relevant industries.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherOxford University Press
dc.relation.ispartofpagefrom492
dc.relation.ispartofpageto494
dc.relation.ispartofissue6
dc.relation.ispartofjournalOccupational Medicine
dc.relation.ispartofvolume66
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1117
dc.titleAlveolar proteinosis associated with aluminium dust inhalation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medicine
gro.hasfulltextNo Full Text
gro.griffith.authorSivakumaran, Pathmanathan
gro.griffith.authorNigam, Sonu
gro.griffith.authorChew, Rusheng


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