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dc.contributor.authorMaki, Kevin C
dc.contributor.authorGuyton, John R
dc.contributor.authorOrringer, Carl E
dc.contributor.authorHamilton-Craig, Ian
dc.contributor.authorAlexander, Dominik D
dc.contributor.authorDavidson, Michael H
dc.description.abstractBackground: Cardiovascular outcomes trials of fibrates, niacin, or omega-3 fatty acids alone, or added to a statin, have not consistently demonstrated reduced risk, but larger, statistically significant clinical benefits have been reported in subgroups with elevated triglycerides (TG) and/or elevated TG plus low high-density lipoprotein cholesterol (HDL-C). Objective: To perform a meta-analysis of the effects of therapies targeting TG and TG-rich lipoprotein cholesterol on cardiovascular disease event risk in subjects with elevated TG or elevated TG paired with low HDL-C. Methods: Publications were identified using PubMed, the Cochrane Central Register of Controlled Trials,, the World Health Organization International Clinical Trials Registry Platform, and Internet Stroke Center. Random-effects meta-analysis models were used to generate summary relative risk estimates and 95% confidence intervals. Heterogeneity was assessed by χ2 and I2 statistics, and the impact of each trial was assessed in one study–removed sensitivity analyses. Results: Six trials of fibrates, 2 of niacin, 1 of fibrate + niacin, and 1 of omega-3 eicosapentaenoic acid ethyl esters were identified. For the prespecified primary cardiovascular disease or coronary heart disease end point used in each trial, the summary relative risk estimate (95% confidence interval) for subjects with elevated TG was 0.82 (0.73–0.91), p-heterogeneity = 0.13, I2 = 36.2, and for subjects with elevated TG and low-HDL-C, it was 0.71 (0.63–0.81), p-heterogeneity = 0.52, I2 = 0.0. There was no evidence of publication bias, and the results remained statistically significant when each individual trial was removed. Conclusion: Drugs that substantially, but not exclusively, lower TG and TG-rich lipoprotein cholesterol may have cardiovascular benefits in individuals with elevated TG, particularly if accompanied by low HDL-C.
dc.relation.ispartofjournalJournal of Clinical Lipidology
dc.subject.fieldofresearchMedical Biochemistry and Metabolomics not elsewhere classified
dc.subject.fieldofresearchMedical Biochemistry and Metabolomics
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematology
dc.titleTriglyceride-lowering therapies reduce cardiovascular disease event risk in subjects with hypertriglyceridemia
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorHamilton-Craig, Ian

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