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  • Biosensing made easy with PEG-targeted bi-specific antibodies

    Author(s)
    Raftery, Lyndon J
    Grewal, Yadveer S
    Howard, Christopher B
    Jones, Martina L
    Shiddiky, Muhammad JA
    Carrascosa, Laura G
    Thurecht, Kristofer J
    Mahler, Stephen M
    Trau, Matt
    Griffith University Author(s)
    Shiddiky, Muhammad J.
    Year published
    2016
    Metadata
    Show full item record
    Abstract
    Whilst recent advances in nanotechnology have yielded many new biosensing capabilities, innovative biological attachment and detection modalities remain relatively underdeveloped. Bi-specific antibodies (bsAbs) – which exhibit binding capability for two separate targets – offer an inherent advantage over conventional antibody reagents by significantly simplifying sensor surface preparation. Herein, we report the deployment of bsAbs for simultaneous attachment to a polymer-coated transducer and label-free, electrochemical (EC) detection of target antigens.Whilst recent advances in nanotechnology have yielded many new biosensing capabilities, innovative biological attachment and detection modalities remain relatively underdeveloped. Bi-specific antibodies (bsAbs) – which exhibit binding capability for two separate targets – offer an inherent advantage over conventional antibody reagents by significantly simplifying sensor surface preparation. Herein, we report the deployment of bsAbs for simultaneous attachment to a polymer-coated transducer and label-free, electrochemical (EC) detection of target antigens.
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    Journal Title
    Chemical Communications
    Volume
    52
    DOI
    https://doi.org/10.1039/c6cc01916a
    Subject
    Chemical sciences
    Other chemical sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/100550
    Collection
    • Journal articles

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