Biosensing made easy with PEG-targeted bi-specific antibodies
Author(s)
Raftery, Lyndon J
Grewal, Yadveer S
Howard, Christopher B
Jones, Martina L
Shiddiky, Muhammad JA
Carrascosa, Laura G
Thurecht, Kristofer J
Mahler, Stephen M
Trau, Matt
Griffith University Author(s)
Year published
2016
Metadata
Show full item recordAbstract
Whilst recent advances in nanotechnology have yielded many new biosensing capabilities, innovative biological attachment and detection modalities remain relatively underdeveloped. Bi-specific antibodies (bsAbs) – which exhibit binding capability for two separate targets – offer an inherent advantage over conventional antibody reagents by significantly simplifying sensor surface preparation. Herein, we report the deployment of bsAbs for simultaneous attachment to a polymer-coated transducer and label-free, electrochemical (EC) detection of target antigens.Whilst recent advances in nanotechnology have yielded many new biosensing capabilities, innovative biological attachment and detection modalities remain relatively underdeveloped. Bi-specific antibodies (bsAbs) – which exhibit binding capability for two separate targets – offer an inherent advantage over conventional antibody reagents by significantly simplifying sensor surface preparation. Herein, we report the deployment of bsAbs for simultaneous attachment to a polymer-coated transducer and label-free, electrochemical (EC) detection of target antigens.
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Journal Title
Chemical Communications
Volume
52
Subject
Chemical sciences
Other chemical sciences not elsewhere classified