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  • Proteomic Analysis of the Schistosoma mansoni Miracidium

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    Author(s)
    Wang, Tianfang
    Zhao, Min
    Rotgans, Bronwyn A
    Strong, April
    Liang, Di
    Ni, Guoying
    Limpanont, Yanin
    Ramasoota, Pongrama
    McManus, Donald P
    Cummins, Scott F
    Griffith University Author(s)
    Ni, Guoying
    Year published
    2016
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    Abstract
    Despite extensive control efforts, schistosomiasis continues to be a major public health problem in developing nations in the tropics and sub-tropics. The miracidium, along with the cercaria, both of which are water-borne and free-living, are the only two stages in the lifecycle of Schistosoma mansoni which are involved in host invasion. Miracidia penetrate intermediate host snails and develop into sporocysts, which lead to cercariae that can infect humans. Infection of the snail host by the miracidium represents an ideal point at which to interrupt the parasite’s life-cycle. This research focuses on an analysis of the ...
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    Despite extensive control efforts, schistosomiasis continues to be a major public health problem in developing nations in the tropics and sub-tropics. The miracidium, along with the cercaria, both of which are water-borne and free-living, are the only two stages in the lifecycle of Schistosoma mansoni which are involved in host invasion. Miracidia penetrate intermediate host snails and develop into sporocysts, which lead to cercariae that can infect humans. Infection of the snail host by the miracidium represents an ideal point at which to interrupt the parasite’s life-cycle. This research focuses on an analysis of the miracidium proteome, including those proteins that are secreted. We have identified a repertoire of proteins in the S. mansoni miracidium at 2 hours post-hatch, including proteases, venom allergen- like proteins, receptors and HSP70, which might play roles in snail-parasite interplay. Proteins involved in energy production and conservation were prevalent, as were proteins predicted to be associated with defence. This study also provides a strong foundation for further understanding the roles that neurohormones play in host-seeking by schistosomes, with the potential for development of novel anthelmintics that interfere with its various lifecycle stages.
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    Journal Title
    PLoS One
    Volume
    11
    Issue
    1
    DOI
    https://doi.org/10.1371/journal.pone.0147247
    Copyright Statement
    © 2016 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Subject
    Medical Parasitology
    Publication URI
    http://hdl.handle.net/10072/100583
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    • Journal articles

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