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  • Increased Serum Levels of IL-17A and IL-23 Are Associated with Decreased Vitamin D3 and Increased Pain in Osteoarthritis

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    Author(s)
    Askari, Alireza
    Naghizadeh, Mohammad Mehdi
    Homayounfar, Reza
    Shahi, Abbas
    Afsarian, Mohammad Hosein
    Paknahad, Abbas
    Kennedy, Derek
    Ataollahi, Mohammad Reza
    Griffith University Author(s)
    Kennedy, Derek D.
    Year published
    2016
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    Abstract
    Introduction Osteoarthritis (OA) is the most common type of arthritis and proinflammatory cytokines have been considered as the main etiologic factor in the pathogenesis of the disease. Serum levels of cytokines, that are associated with innate immunity and TH1 cells, have been analyzed in OA patients, however, there is limited research that profiles cytokines associated with Th17 cells and their relation to vitamin D3 and pain. Material and methods The sera from 131 patients with OA and 262 healthy controls were evaluated for serum levels of IL-17A, IL-21, IL-23 and vitamin D3 using ELISA. Results Serum levels of IL-17A, ...
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    Introduction Osteoarthritis (OA) is the most common type of arthritis and proinflammatory cytokines have been considered as the main etiologic factor in the pathogenesis of the disease. Serum levels of cytokines, that are associated with innate immunity and TH1 cells, have been analyzed in OA patients, however, there is limited research that profiles cytokines associated with Th17 cells and their relation to vitamin D3 and pain. Material and methods The sera from 131 patients with OA and 262 healthy controls were evaluated for serum levels of IL-17A, IL-21, IL-23 and vitamin D3 using ELISA. Results Serum levels of IL-17A, and IL-23 were statistically higher in OA patients than in healthy controls, while IL-21 and vitamin D3 were significantly lower in OA patients when compared to controls. A significant positive correlation was found between the serum levels of IL-17A and IL-23 using WOMAC pain scores and vitamin D3 serum levels. Discussion The results suggest that IL-17A plays a significant role in OA pathogenesis and the induction of pain. Decreased serum levels of vitamin D3 may reflect a positive role played by the factor in the regulation of immune responses in OA patients.
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    Journal Title
    PLoS One
    Volume
    11
    Issue
    11
    DOI
    https://doi.org/10.1371/journal.pone.0164757
    Copyright Statement
    © 2016 Askari et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Subject
    Clinical Pharmacology and Therapeutics
    Publication URI
    http://hdl.handle.net/10072/100597
    Collection
    • Journal articles

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