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dc.contributor.authorAskari, Alireza
dc.contributor.authorNaghizadeh, Mohammad Mehdi
dc.contributor.authorHomayounfar, Reza
dc.contributor.authorShahi, Abbas
dc.contributor.authorAfsarian, Mohammad Hosein
dc.contributor.authorPaknahad, Abbas
dc.contributor.authorKennedy, Derek
dc.contributor.authorAtaollahi, Mohammad Reza
dc.date.accessioned2018-01-05T05:13:45Z
dc.date.available2018-01-05T05:13:45Z
dc.date.issued2016
dc.identifier.issn1932-6203
dc.identifier.doi10.1371/journal.pone.0164757
dc.identifier.urihttp://hdl.handle.net/10072/100597
dc.description.abstractIntroduction Osteoarthritis (OA) is the most common type of arthritis and proinflammatory cytokines have been considered as the main etiologic factor in the pathogenesis of the disease. Serum levels of cytokines, that are associated with innate immunity and TH1 cells, have been analyzed in OA patients, however, there is limited research that profiles cytokines associated with Th17 cells and their relation to vitamin D3 and pain. Material and methods The sera from 131 patients with OA and 262 healthy controls were evaluated for serum levels of IL-17A, IL-21, IL-23 and vitamin D3 using ELISA. Results Serum levels of IL-17A, and IL-23 were statistically higher in OA patients than in healthy controls, while IL-21 and vitamin D3 were significantly lower in OA patients when compared to controls. A significant positive correlation was found between the serum levels of IL-17A and IL-23 using WOMAC pain scores and vitamin D3 serum levels. Discussion The results suggest that IL-17A plays a significant role in OA pathogenesis and the induction of pain. Decreased serum levels of vitamin D3 may reflect a positive role played by the factor in the regulation of immune responses in OA patients.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherPublic Library of Sciences
dc.relation.ispartofpagefrome0164757-1
dc.relation.ispartofpagetoe0164757-8
dc.relation.ispartofissue11
dc.relation.ispartofjournalPLoS One
dc.relation.ispartofvolume11
dc.subject.fieldofresearchClinical Pharmacology and Therapeutics
dc.subject.fieldofresearchcode111502
dc.titleIncreased Serum Levels of IL-17A and IL-23 Are Associated with Decreased Vitamin D3 and Increased Pain in Osteoarthritis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.description.versionPublished
gro.rights.copyright© 2016 Askari et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.hasfulltextFull Text
gro.griffith.authorKennedy, Derek D.


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