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dc.contributor.authorAskari, Azadeh
dc.contributor.authorNosratabadi, Reza
dc.contributor.authorKhaleghinia, Mehdi
dc.contributor.authorZainodini, Nahid
dc.contributor.authorKennedy, Derek
dc.contributor.authorShabani, Ziba
dc.contributor.authorArababadi, Mohammad Kazemi
dc.date.accessioned2018-01-05T05:15:11Z
dc.date.available2018-01-05T05:15:11Z
dc.date.issued2016
dc.identifier.issn0882-8245
dc.identifier.doi10.1089/vim.2016.0045
dc.identifier.urihttp://hdl.handle.net/10072/100616
dc.description.abstractNucleotide-binding domain leucine repeats (NLRs) are required for the recognition of various molecules that are expressed within microbes and are able to actuate appropriate immune responses via activation of cytokines. The current study evaluates the expression levels of NLRP1 and NLRC4, which are components of inflammasomes, in chronic hepatitis B (CHB) virus-infected patients. This study recruited two series of CHB patients (each contained 60 patients) and 60 healthy controls. Real-time polymerase chain reaction (PCR) was employed to evaluate mRNA expression levels of NLRP1, NLRP3, and NLRC4 as well as hepatitis B virus (HBV)-DNA copy number. Serum levels of liver markers were also used to evaluate the patients. Hepatitis B envelope antigen (HBeAg) and hepatitis B surface antigen (HBsAg) were also examined in all patients to evaluate infection. The data showed that expression levels of NLRC4 and NLRP1 were not significantly different in circulating monocytes of CHB patients when compared with those of healthy controls. Furthermore, the data indicate that mRNA levels of NLRP1, NLRP3, and NLRC4 were also not altered in CHB patients regardless of HBV-DNA copy numbers/mL and HBeAg status. The data revealed that mRNA expression levels of NLRP1 and NLRC4 were not altered in CHB patients, suggesting that these genes are not responsible for the impaired immune responses against HBV observed in these patients.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMary Ann Liebert
dc.relation.ispartofpagefrom496
dc.relation.ispartofpageto501
dc.relation.ispartofissue9
dc.relation.ispartofjournalViral Immunology
dc.relation.ispartofvolume29
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode110799
dc.subject.fieldofresearchcode1107
dc.titleEvaluation of NLRC4, NLRP1, and NLRP3, as Components of Inflammasomes, in Chronic Hepatitis B Virus-Infected Patients
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorKennedy, Derek D.


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