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dc.contributor.authorLiu, Jinfengen_US
dc.contributor.authorDong, Huanshengen_US
dc.contributor.authorZhang, Yongen_US
dc.contributor.authorCao, Mingjunen_US
dc.contributor.authorSong, Lilien_US
dc.contributor.authorPan, Qingjieen_US
dc.contributor.authorBulmer, Andrewen_US
dc.contributor.authorAdams, Daviden_US
dc.contributor.authorDong, Xiaoen_US
dc.contributor.authorWang, Hongjunen_US
dc.date.accessioned2017-05-03T12:34:21Z
dc.date.available2017-05-03T12:34:21Z
dc.date.issued2015en_US
dc.identifier.issn2045-2322en_US
dc.identifier.doi10.1038/srep09886en_US
dc.identifier.urihttp://hdl.handle.net/10072/100663
dc.description.abstractObesity can cause insulin resistance and type 2 diabetes. Moderate elevations in bilirubin levels have anti-diabetic effects. This study is aimed at determining the mechanisms by which bilirubin treatment reduces obesity and insulin resistance in a diet-induced obesity (DIO) mouse model. DIO mice were treated with bilirubin or vehicle for 14 days. Body weights, plasma glucose, and insulin tolerance tests were performed prior to, immediately, and 7 weeks post-treatment. Serum lipid, leptin, adiponectin, insulin, total and direct bilirubin levels were measured. Expression of factors involved in adipose metabolism including sterol regulatory element-binding protein (SREBP-1), insulin receptor (IR), and PPARγ in liver were measured by RT-PCR and Western blot. Compared to controls, bilirubin-treated mice exhibited reductions in body weight, blood glucose levels, total cholesterol (TC), leptin, total and direct bilirubin, and increases in adiponectin and expression of SREBP-1, IR, and PPARγ mRNA. The improved metabolic control achieved by bilirubin-treated mice was persistent: at two months after treatment termination, bilirubin-treated DIO mice remained insulin sensitive with lower leptin and higher adiponectin levels, together with increased PPARγ expression. These results indicate that bilirubin regulates cholesterol metabolism, adipokines and PPARγ levels, which likely contribute to increased insulin sensitivity and glucose tolerance in DIO mice.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofpagefrom9886-1en_US
dc.relation.ispartofpageto9886-11en_US
dc.relation.ispartofjournalScientific Reportsen_US
dc.relation.ispartofvolume5en_US
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classifieden_US
dc.subject.fieldofresearchcode060199en_US
dc.titleBilirubin Increases Insulin Sensitivity by Regulating Cholesterol Metabolism, Adipokines and PPARγ Levelsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.description.versionPublisheden_US
gro.rights.copyright© The Author(s) 2015. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en_US
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