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dc.contributor.authorPagani, Luca
dc.contributor.authorLawson, Daniel John
dc.contributor.authorJagoda, Evelyn
dc.contributor.authorMoerseburg, Alexander
dc.contributor.authorEriksson, Anders
dc.contributor.authorMitt, Mario
dc.contributor.authorClemente, Florian
dc.contributor.authorHudjashov, Georgi
dc.contributor.authorDeGiorgio, Michael
dc.contributor.authorSaag, Lauri
dc.contributor.authorWall, Jeffrey D
dc.contributor.authorCardona, Alexia
dc.contributor.authorMaegi, Reedik
dc.contributor.authorSayres, Melissa A Wilson
dc.contributor.authorKaewert, Sarah
dc.contributor.authorInchley, Charlotte
dc.contributor.authorScheib, Christiana L
dc.contributor.authorJaerve, Mari
dc.contributor.authorKarmin, Monika
dc.contributor.authorJacobs, Guy S
dc.contributor.authorAntao, Tiago
dc.contributor.authorIliescu, Florin Mircea
dc.contributor.authorKushniarevich, Alena
dc.contributor.authorAyub, Qasim
dc.contributor.authorTyler-Smith, Chris
dc.contributor.authorXue, Yali
dc.contributor.authorYunusbayev, Bayazit
dc.contributor.authorTambets, Kristiina
dc.contributor.authorMallick, Chandana Basu
dc.contributor.authorSaag, Lehti
dc.contributor.authorPocheshkhova, Elvira
dc.contributor.authorAndriadze, George
dc.contributor.authorMuller, Craig
dc.contributor.authorWestaway, Michael C
dc.contributor.authorLambert, David M
dc.contributor.authorZoraqi, Grigor
dc.contributor.authorTurdikulova, Shahlo
dc.contributor.authorDalimova, Dilbar
dc.contributor.authorSabitov, Zhaxylyk
dc.contributor.authorSultana, Gazi Nurun Nahar
dc.contributor.authorLachance, Joseph
dc.contributor.authorTishkoff, Sarah
dc.contributor.authorMomynaliev, Kuvat
dc.contributor.authorIsakova, Jainagul
dc.contributor.authorDamba, Larisa D
dc.contributor.authorGubina, Marina
dc.contributor.authorNymadawa, Pagbajabyn
dc.contributor.authorEvseeva, Irina
dc.contributor.authorAtramentova, Lubov
dc.contributor.authorUtevska, Olga
dc.contributor.authorRicaut, Francois-Xavier
dc.contributor.authorBrucato, Nicolas
dc.contributor.authorSudoyo, Herawati
dc.contributor.authorLetellier, Thierry
dc.contributor.authorCox, Murray P
dc.contributor.authorBarashkov, Nikolay A
dc.contributor.authorSkaro, Vedrana
dc.contributor.authorMulahasanovic, Lejla
dc.contributor.authorPrimorac, Dragan
dc.contributor.authorSahakyan, Hovhannes
dc.contributor.authorMormina, Maru
dc.contributor.authorEichstaedt, Christina A
dc.contributor.authorLichman, Daria V
dc.contributor.authorAbdullah, Syafiq
dc.contributor.authorChaubey, Gyaneshwer
dc.contributor.authorWee, Joseph TS
dc.contributor.authorMihailov, Evelin
dc.contributor.authorKarunas, Alexandra
dc.contributor.authorLitvinov, Sergei
dc.contributor.authorKhusainova, Rita
dc.contributor.authorEkomasova, Natalya
dc.contributor.authorAkhmetova, Vita
dc.contributor.authorKhidiyatova, Irina
dc.contributor.authorMarjanovi, Damir
dc.contributor.authorYepiskoposyan, Levon
dc.contributor.authorBehar, Doron M
dc.contributor.authorBalanovska, Elena
dc.contributor.authorMetspalu, Andres
dc.contributor.authorDerenko, Miroslava
dc.contributor.authorMalyarchuk, Boris
dc.contributor.authorVoevoda, Mikhail
dc.contributor.authorFedorova, Sardana A
dc.contributor.authorOsipova, Ludmila P
dc.contributor.authorMirazon, Marta
dc.contributor.authorGerbault, Pascale
dc.contributor.authorLeavesley, Matthew
dc.contributor.authorMigliano, Andrea Bamberg
dc.contributor.authorPetraglia, Michael
dc.contributor.authorBalanovsky, Oleg
dc.contributor.authorKhusnutdinova, Elza K
dc.contributor.authorMetspalu, Ene
dc.contributor.authorThomas, Mark G
dc.contributor.authorManica, Andrea
dc.contributor.authorNielsen, Rasmus
dc.contributor.authorVillems, Richard
dc.contributor.authorWillerslev, Eske
dc.contributor.authorKivisild, Toomas
dc.contributor.authorMetspalu, Mait
dc.date.accessioned2017-12-08T06:26:27Z
dc.date.available2017-12-08T06:26:27Z
dc.date.issued2016
dc.identifier.issn0028-0836
dc.identifier.doi10.1038/nature19792
dc.identifier.urihttp://hdl.handle.net/10072/100692
dc.description.abstractHigh-coverage whole-genome sequence studies have so far focused on a limited number1 of geographically restricted populations2,3,4,5, or been targeted at specific diseases, such as cancer6. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring population history7,8,9 and refuelled the debate on the mutation rate in humans10. Here we present the Estonian Biocentre Human Genome Diversity Panel (EGDP), a dataset of 483 high-coverage human genomes from 148 populations worldwide, including 379 new genomes from 125 populations, which we group into diversity and selection sets. We analyse this dataset to refine estimates of continent-wide patterns of heterozygosity, long- and short-distance gene flow, archaic admixture, and changes in effective population size through time as well as for signals of positive or balancing selection. We find a genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa. Together with evidence from the western Asian fossil record11, and admixture between AMHs and Neanderthals predating the main Eurasian expansion12, our results contribute to the mounting evidence for the presence of AMHs out of Africa earlier than 75,000 years ago.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing
dc.relation.ispartofpagefrom238
dc.relation.ispartofpageto242
dc.relation.ispartofjournalNature
dc.relation.ispartofvolume538
dc.subject.fieldofresearchGenomics
dc.subject.fieldofresearchcode310509
dc.titleGenomic analyses inform on migration events during the peopling of Eurasia
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorLambert, David M.
gro.griffith.authorWestaway, Michael
gro.griffith.authorWillerslev, Eske
gro.griffith.authorPetraglia, Michael


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