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dc.contributor.authorKorhonen, Pasi K
dc.contributor.authorPozio, Edoardo
dc.contributor.authorLa Rosa, Giuseppe
dc.contributor.authorChang, Bill CH
dc.contributor.authorKoehler, Anson V
dc.contributor.authorHoberg, Eric P
dc.contributor.authorBoag, Peter R
dc.contributor.authorTan, Patrick
dc.contributor.authorJex, Aaron R
dc.contributor.authorHofmann, Andreas
dc.contributor.authorSternberg, Paul W
dc.contributor.authorYoung, Neil D
dc.contributor.authorGasser, Robin B
dc.date.accessioned2017-12-14T00:11:18Z
dc.date.available2017-12-14T00:11:18Z
dc.date.issued2016
dc.identifier.issn2041-1723
dc.identifier.doi10.1038/ncomms10513
dc.identifier.urihttp://hdl.handle.net/10072/100696
dc.description.abstractTrichinellosis is a globally important food-borne parasitic disease of humans caused by roundworms of the Trichinella complex. Extensive biological diversity is reflected in substantial ecological and genetic variability within and among Trichinella taxa, and major controversy surrounds the systematics of this complex. Here we report the sequencing and assembly of 16 draft genomes representing all 12 recognized Trichinella species and genotypes, define protein-coding gene sets and assess genetic differences among these taxa. Using thousands of shared single-copy orthologous gene sequences, we fully reconstruct, for the first time, a phylogeny and biogeography for the Trichinella complex, and show that encapsulated and non-encapsulated Trichinella taxa diverged from their most recent common ancestor ∼21 million years ago (mya), with taxon diversifications commencing ∼10−7 mya.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofpagefrom10513-1
dc.relation.ispartofpageto10513-8
dc.relation.ispartofjournalNature Communications
dc.relation.ispartofvolume7
dc.subject.fieldofresearchMedical parasitology
dc.subject.fieldofresearchcode320704
dc.titlePhylogenomic and biogeographic reconstruction of the Trichinella complex
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
gro.hasfulltextFull Text
gro.griffith.authorHofmann, Andreas


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