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dc.contributor.authorDay, Christopher J
dc.contributor.authorKing, Rebecca M
dc.contributor.authorShewell, Lucy K
dc.contributor.authorTram, Greg
dc.contributor.authorNajnin, Tahria
dc.contributor.authorHartley-Tassell, Lauren E
dc.contributor.authorWilson, Jennifer C
dc.contributor.authorFleetwood, Aaron D
dc.contributor.authorZhulin, Igor B
dc.contributor.authorKorolik, Victoria
dc.date.accessioned2018-01-18T03:51:18Z
dc.date.available2018-01-18T03:51:18Z
dc.date.issued2016
dc.identifier.issn2041-1723
dc.identifier.doi10.1038/ncomms13206
dc.identifier.urihttp://hdl.handle.net/10072/100697
dc.description.abstractA rare chemotaxis receptor, Tlp11, has been previously identified in invasive strains of Campylobacter jejuni, the most prevalent cause of bacterial gastroenteritis worldwide. Here we use glycan and small-molecule arrays, as well as surface plasmon resonance, to show that Tlp11 specifically interacts with galactose. Tlp11 is required for the chemotactic response of C. jejuni to galactose, as shown using wild type, allelic inactivation and addition mutants. The inactivated mutant displays reduced virulence in vivo, in a model of chicken colonization. The Tlp11 sensory domain represents the first known sugar-binding dCache_1 domain, which is the most abundant family of extracellular sensors in bacteria. The Tlp11 signalling domain interacts with the chemotaxis scaffolding proteins CheV and CheW, and comparative genomic analysis indicates a likely recent evolutionary origin for Tlp11. We propose to rename Tlp11 as CcrG, Campylobacter ChemoReceptor for Galactose.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofpagefrom13206-1
dc.relation.ispartofpageto13206-8
dc.relation.ispartofjournalNature Communications
dc.relation.ispartofvolume7
dc.subject.fieldofresearchBacteriology
dc.subject.fieldofresearchcode060501
dc.titleA direct-sensing galactose chemoreceptor recently evolved in invasive strains of Campylobacter jejuni
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2016 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
gro.hasfulltextFull Text
gro.griffith.authorWilson, Jennifer
gro.griffith.authorKorolik, Victoria
gro.griffith.authorHartley-Tassell, Lauren E.
gro.griffith.authorDay, Christopher J.
gro.griffith.authorKing, Bec M.
gro.griffith.authorShewell, Lucy K.
gro.griffith.authorTram, Greg C.
gro.griffith.authorNajnin, Tahria
gro.griffith.authorWilson, Jenny C.


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