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  • Macrolactam analogues of macrolide natural products

    Author(s)
    Hugel, Helmut M
    Smith, Andrew T
    Rizzacasa, Mark A
    Griffith University Author(s)
    Smith, Andrew T.
    Year published
    2016
    Metadata
    Show full item record
    Abstract
    The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity. The methods for the synthesis of several lactam analogues of macrolide natural products are highlighted and aspects of their biological properties presented.The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity. The methods for the synthesis of several lactam analogues of macrolide natural products are highlighted and aspects of their biological properties presented.
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    Journal Title
    Organic & Biomolecular Chemistry
    Volume
    14
    DOI
    https://doi.org/10.1039/C6OB02149B
    Subject
    Medicinal and biomolecular chemistry
    Medicinal and biomolecular chemistry not elsewhere classified
    Organic chemistry
    Publication URI
    http://hdl.handle.net/10072/100706
    Collection
    • Journal articles

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