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dc.contributor.authorZeng, Hanri
dc.contributor.authorLu, Jing
dc.contributor.authorZheng, Huanying
dc.contributor.authorYi, Lina
dc.contributor.authorGuo, Xue
dc.contributor.authorLiu, Leng
dc.contributor.authorRutherford, Shannon
dc.contributor.authorSun, Limei
dc.contributor.authorTan, Xiaohua
dc.contributor.authorLi, Hui
dc.contributor.authorKe, Changwen
dc.contributor.authorLin, Jinyan
dc.date.accessioned2017-05-03T12:34:46Z
dc.date.available2017-05-03T12:34:46Z
dc.date.issued2015
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/srep10550
dc.identifier.urihttp://hdl.handle.net/10072/100734
dc.description.abstractEnterovirus A71 (EVA71) and Coxsackievirus A16 (CVA16) are regarded as the two major causative pathogens in hand, foot and mouth disease (HFMD) epidemics. However, CVA6, previously largely ignored, became the predominant pathogen in China in 2013. In this study, we describe the epidemiological trendsofCVA6 during the annual HFMD outbreaks from 2008 to 2013 in Guangdong, China. The study results show that CVA6 has been one of three major causative agents of HFMD epidemics since 2009. The periodic rotation and dominance of the three pathogens, EVA71, CVA16 and CVA6, may have contributed to the continuously increasing HFMD epidemics. Moreover, phylogenetic analysis of the VP1 gene shows that major circulating CVA6 strains collected from 2009 to 2013 are distinct from the earlier strains collected before 2009. In conclusion, the discovery from this research investigating epidemiological trends of CVA6 from 2008 to 2013 explains the possible pattern of the continuous HFMD epidemic in China. The etiological change pattern also highlights the need for improvement for pathogen surveillance and vaccine strategies for HFMD control in China.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherNature Publishing Group
dc.relation.ispartofpagefrom10550-1
dc.relation.ispartofpageto10550-8
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume5
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classified
dc.subject.fieldofresearchcode060199
dc.titleThe epidemiological study of Coxsackievirus A6 revealing hand, foot and mouth disease epidemic patterns in Guangdong, China
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionPublished
gro.rights.copyright© The Author(s) 2015. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
gro.hasfulltextFull Text
gro.griffith.authorRutherford, Shannon


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