Show simple item record

dc.contributor.authorDay, C
dc.contributor.authorKim, M
dc.contributor.authorNicholson, G
dc.contributor.authorMorrison, NA
dc.date.accessioned2017-05-03T11:03:04Z
dc.date.available2017-05-03T11:03:04Z
dc.date.issued2003
dc.date.modified2007-03-12T08:12:59Z
dc.identifier.issn0884-0431
dc.identifier.urihttp://hdl.handle.net/10072/10077
dc.description.abstractSurprisingly, very few transcription factors have been implicated in osteoclast differentiation. Newly discovered upregulated transcription factors are obviously important in understanding osteoclast differentiation. However, we speculate that repression of transcription factor genes may also be necessary for osteoclast differentiation. In particular, we have looked for differential regulation of transcription factors between the two alternative states: macrophage and osteoclast. Two recent papers verified the role of NFATc1 in osteoclastogenesis [1,2]; NFATc1 is required for the production of TRAP positive multinucleated osteoclast like cells (OCLs). We show here that NFATc1 and other transcription factors are strongly induced by RANKL in human osteoclast like cells. NFATc1 regulation steadily increases across time with a peak of 26 fold at three weeks post treatment with macrophage colony stimulating factor (M-CSF) and RANKL. Along with NFATc1 we have observed significant up-regulation of four other transcription factors: GA-binding protein a and b (GABP), early response growth factor 1 (EGR-1), and FUSE binding protein (FBP). The dynamics of regulation of ERG-1 and GABPa and b were identical to that of NFATc1. However FBP regulation peaks earlier and is of great magnitude. These data show that NFATc1 is not the only strongly regulated transcription factor in osteoclast differentiation and is later induced than FBP.
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAMER SOC BONE & MINERAL RES
dc.publisher.placeWASHINGTON, DC, USA
dc.relation.ispartofconferencename25th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research
dc.relation.ispartofconferencetitleJOURNAL OF BONE AND MINERAL RESEARCH
dc.relation.ispartofdatefrom2003-09-19
dc.relation.ispartofdateto2003-09-23
dc.relation.ispartoflocationMINNEAPOLIS, MINNESOTA
dc.relation.ispartofpagefromS235
dc.relation.ispartofpagefrom1 pages
dc.relation.ispartofpagetoS235
dc.relation.ispartofpageto1 pages
dc.relation.ispartofvolume18
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode40
dc.subject.fieldofresearchcode32
dc.titleTranscription factors involved in osteoclastogenesis.
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dc.type.codeE - Conference Publications
gro.date.issued2003
gro.hasfulltextNo Full Text
gro.griffith.authorMorrison, Nigel A.
gro.griffith.authorDay, Christopher J.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Conference outputs
    Contains papers delivered by Griffith authors at national and international conferences.

Show simple item record