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dc.contributor.authorMarshall-Gradisnik, Sonya
dc.contributor.authorJohnston, Samantha
dc.contributor.authorChacko, Anu
dc.contributor.authorNguyen, Thao
dc.contributor.authorSmith, Peter
dc.contributor.authorStaines, Donald
dc.date.accessioned2018-01-19T03:30:38Z
dc.date.available2018-01-19T03:30:38Z
dc.date.issued2016
dc.identifier.issn0300-0605
dc.identifier.doi10.1177/0300060516671622
dc.identifier.urihttp://hdl.handle.net/10072/100846
dc.description.abstractObjective: The pathomechanism of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ ME) is unknown; however, a small subgroup of patients has shown muscarinic antibody positivity and reduced symptom presentation following anti-CD20 intervention. Given the important roles of calcium (Ca2þ) and acetylcholine (ACh) signalling in B cell activation and potential antibody development, we aimed to identify relevant single nucleotide polymorphisms (SNPs) and genotypes in isolated B cells from CFS/ME patients. Methods: A total of 11 CFS/ME patients (aged 31.82 5.50 years) and 11 non-fatigued controls (aged 33.91 5.06 years) were included. Flow cytometric protocols were used to determine B cell purity, followed by SNP and genotype analysis for 21 mammalian TRP ion channel genes and nine mammalian ACh receptor genes. SNP association and genotyping analysis were performed using ANOVA and PLINK analysis software.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSage Publications
dc.relation.ispartofpagefrom1381
dc.relation.ispartofpageto1394
dc.relation.ispartofissue6
dc.relation.ispartofjournalJournal of International Medical Research
dc.relation.ispartofvolume44
dc.subject.fieldofresearchGenomics
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchHealth sciences
dc.subject.fieldofresearchcode310509
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode42
dc.titleSingle nucleotide polymorphisms and genotypes of transient receptor potential ion channel and acetylcholine receptor genes from isolated B lymphocytes in myalgic encephalomyelitis/chronic fatigue syndrome patients
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by-nc/3.0/
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2016 This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us. sagepub.com/en-us/nam/open-access-at-sage).
gro.hasfulltextFull Text
gro.griffith.authorStaines, Donald R.
gro.griffith.authorMarshall-Gradisnik, Sonya M.


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