Lack of Association Between Superoxide Dismutase Gene Polymorphism and Malignant Lymphoproliferative Disorders

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Author(s)
Nakhaee, Alireza
Mashhadi, Mohammad Ali
Zademir, Mohaddeseh
Sepehri, Zahra
Kennedy, Derek
Griffith University Author(s)
Year published
2016
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Background: Superoxide dismutase is one of the most important antioxidant enzymes that protect cells against destructive effects of superoxide anion.
Objectives: The aim of this study was to evaluate the association between the C47T polymorphism (rs4880) of the manganese superoxide dismutase (Mn-SOD) gene and the risk of malignant lymphoproliferative disorders (MLDs).
Patients and Methods: Manganese superoxide dismutase polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 103 patients with MLDs and 103 healthy control subjects.
Results: The frequencies of the ...
View more >Background: Superoxide dismutase is one of the most important antioxidant enzymes that protect cells against destructive effects of superoxide anion. Objectives: The aim of this study was to evaluate the association between the C47T polymorphism (rs4880) of the manganese superoxide dismutase (Mn-SOD) gene and the risk of malignant lymphoproliferative disorders (MLDs). Patients and Methods: Manganese superoxide dismutase polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 103 patients with MLDs and 103 healthy control subjects. Results: The frequencies of the CC, CT and TT genotypes were 29.1%, 51.5% and 19.4%, respectively, in patients with MLDs and 24.3%, 47.6% and 28.2%, respectively, in the control group. There were no statistical differences in the genotype or allele frequency of rs4880 between cases and controls. Conclusions: According to the fact that Mn-SOD gene polymorphisms have been considered as a major risk factor in some malignancies, this single center study did not find any association between the rs4880 polymorphism of the manganese superoxide dismutase gene and risk of MLDs.
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View more >Background: Superoxide dismutase is one of the most important antioxidant enzymes that protect cells against destructive effects of superoxide anion. Objectives: The aim of this study was to evaluate the association between the C47T polymorphism (rs4880) of the manganese superoxide dismutase (Mn-SOD) gene and the risk of malignant lymphoproliferative disorders (MLDs). Patients and Methods: Manganese superoxide dismutase polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 103 patients with MLDs and 103 healthy control subjects. Results: The frequencies of the CC, CT and TT genotypes were 29.1%, 51.5% and 19.4%, respectively, in patients with MLDs and 24.3%, 47.6% and 28.2%, respectively, in the control group. There were no statistical differences in the genotype or allele frequency of rs4880 between cases and controls. Conclusions: According to the fact that Mn-SOD gene polymorphisms have been considered as a major risk factor in some malignancies, this single center study did not find any association between the rs4880 polymorphism of the manganese superoxide dismutase gene and risk of MLDs.
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Journal Title
Gene, Cell and Tissue
Volume
3
Issue
3
Copyright Statement
© The Author(s) 2016. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Subject
Biochemistry and Cell Biology not elsewhere classified
Medical Genetics (excl. Cancer Genetics)