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  • Recent developments of small molecule chemical probes for fluorescence-based detection of human carbonic anhydrase II and IX

    Author(s)
    Teruya, Kanae
    Tonissen, Kathryn F
    Poulsen, Sally-Ann
    Griffith University Author(s)
    Poulsen, Sally-Ann
    Tonissen, Kathryn F.
    Year published
    2016
    Metadata
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    Abstract
    The development of small molecule affinity-based chemical probes as research tools for studying the role of carbonic anhydrases (CAs) in their wider biological context has become an active field of research owing to an increasing awareness of the therapeutic relevance of this enzyme family, particularly in cancer. High CA isozyme selectivity, low nonspecific labeling, and efficient labeling yield are the characteristics of an ideal chemical probe, however achieving an effective balance of all three properties is challenging. The progress of this field, with a focus on the diversity of chemical probe designs and the methodologies ...
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    The development of small molecule affinity-based chemical probes as research tools for studying the role of carbonic anhydrases (CAs) in their wider biological context has become an active field of research owing to an increasing awareness of the therapeutic relevance of this enzyme family, particularly in cancer. High CA isozyme selectivity, low nonspecific labeling, and efficient labeling yield are the characteristics of an ideal chemical probe, however achieving an effective balance of all three properties is challenging. The progress of this field, with a focus on the diversity of chemical probe designs and the methodologies employed to accomplish target-selective labeling, is reviewed. The lessons learned from this continuous development have the potential to be more broadly applied to other targets where a delicate balance of the properties impacting the target specificity of a small molecule chemical probe must be managed.
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    Journal Title
    MedChemComm
    Volume
    7
    Issue
    11
    DOI
    https://doi.org/10.1039/c6md00296j
    Subject
    Medicinal and biomolecular chemistry
    Medicinal and biomolecular chemistry not elsewhere classified
    Organic chemistry
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/100928
    Collection
    • Journal articles

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