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  • Anodized 3D–printed titanium implants with dual micro- and nano-scale topography promote interaction with human osteoblasts and osteocyte-like cells

    Author(s)
    Gulati, Karan
    Prideaux, Matthew
    Kogawa, Masakazu
    Lima-Marques, Luis
    Atkins, Gerald J
    Findlay, David M
    Losic, Dusan
    Griffith University Author(s)
    Gulati, Karan
    Year published
    2017
    Metadata
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    Abstract
    The success of implantation of materials into bone is governed by effective osseointegration, requiring biocompatibility of the material and the attachment and differentiation of osteoblastic cells. To enhance cellular function in response to the implant surface, micro‐ and nano‐scale topography have been suggested as essential. In this study, we present bone implants based on 3D–printed titanium alloy (Ti6Al4V), with a unique dual topography composed of micron‐sized spherical particles and vertically aligned titania nanotubes. The implants were prepared by combination of 3D–printing and anodization processes, which are ...
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    The success of implantation of materials into bone is governed by effective osseointegration, requiring biocompatibility of the material and the attachment and differentiation of osteoblastic cells. To enhance cellular function in response to the implant surface, micro‐ and nano‐scale topography have been suggested as essential. In this study, we present bone implants based on 3D–printed titanium alloy (Ti6Al4V), with a unique dual topography composed of micron‐sized spherical particles and vertically aligned titania nanotubes. The implants were prepared by combination of 3D–printing and anodization processes, which are scalable, simple and cost‐effective. The osseointegration properties of fabricated implants, examined using human osteoblasts, showed enhanced adhesion of osteoblasts compared with titanium materials commonly used as orthopaedic implants. Gene expression studies at early (day 7) and late (day 21) stages of culture were consistent with the Ti substrates inducing an osteoblast phenotype conducive to effective osseointegration. These implants with the unique combination of micro‐ and nano‐scale topography are proposed as the new generation of multi‐functional bone implants, suitable for addressing many orthopaedic challenges, including implant rejection, poor osseointegration, inflammation, drug delivery and bone healing.
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    Journal Title
    Journal of Tissue Engineering and Regenerative Medicine
    DOI
    https://doi.org/10.1002/term.2239
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Biomedical engineering
    Biomaterials
    Clinical sciences
    Medical physiology
    Publication URI
    http://hdl.handle.net/10072/101035
    Collection
    • Journal articles

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