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dc.contributor.authorChoomuenwai, Vanida
dc.contributor.authorBeattie, Karren D
dc.contributor.authorHealy, Peter C
dc.contributor.authorAndrews, Katherine T
dc.contributor.authorFechner, Nigel
dc.contributor.authorDavis, Rohan A
dc.date.accessioned2019-02-28T05:39:50Z
dc.date.available2019-02-28T05:39:50Z
dc.date.issued2015
dc.identifier.issn0031-9422
dc.identifier.doi10.1016/j.phytochem.2015.05.018
dc.identifier.urihttp://hdl.handle.net/10072/101319
dc.description.abstractBioassay-guided fractionation of an antimalarial DCM/MeOH extract derived from the Australian rainforest fungus Entonaema sp. resulted in the isolation of three new isoindolinone derivatives, entonalactams A–C (1–3), along with the known natural products 3-methoxy-5-methylbenzene-1,2-diol (4), daldinal B (5), and ergosta-4,6,8(14),22-tetraen-3-one (6). The chemical structures of the new secondary metabolites were determined following extensive 1D/2D NMR and MS data analysis. A single crystal X-ray structure for entonalactam A (1) confirmed the NMR-based structure assignment. Entonalactams A–C (1–3) were all determined to be racemic based on chiro-optical data. All secondary metabolites were tested in vitro against Plasmodium falciparum malaria parasites, and ergosta-4,6,8(14),22-tetraen-3-one (6) was identified as the most active compound with 66% inhibition at 50 μM.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherPergamon
dc.relation.ispartofpagefrom10
dc.relation.ispartofpageto16
dc.relation.ispartofissue1
dc.relation.ispartofjournalPhytochemistry
dc.relation.ispartofvolume117
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry not elsewhere classified
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchcode030499
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode06
dc.titleEntonalactams A-C: Isoindolinone derivatives from an Australian rainforest fungus belonging to the genus Entonaema
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.hasfulltextNo Full Text
gro.griffith.authorHealy, Peter C.
gro.griffith.authorAndrews, Katherine T.
gro.griffith.authorDavis, Rohan A.
gro.griffith.authorMitchell, Karren D.
gro.griffith.authorChoomuenwai, Vanida


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