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  • Neuroinflammation and comorbidities are frequently ignored factors in CNS pathology

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    Author(s)
    Sandu, Raluca Elena
    Buga, Ana Maria
    Uzoni, Adriana
    Petcu, Eugen Bogdan
    Pop-Wagner, Aurel
    Griffith University Author(s)
    Petcu, Eugen B.
    Popa-Wagner, Aurel
    Year published
    2015
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    Abstract
    Virtually all drug interventions that have been successful pre-clinically in experimental stroke have failed to prove their efficacy in a clinical setting. This could be partly explained by the complexity and heterogeneity of human diseases as well as the associated co-morbidities which may render neuroprotective drugs less efficacious in clinical practice. One aspect of crucial importance in the physiopathology of stroke which is not completely understood is neuroinflammation. At the present time, it is becoming evident that subtle, but continuous neuroinflammation can provide the ground for disorders such as cerebral small ...
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    Virtually all drug interventions that have been successful pre-clinically in experimental stroke have failed to prove their efficacy in a clinical setting. This could be partly explained by the complexity and heterogeneity of human diseases as well as the associated co-morbidities which may render neuroprotective drugs less efficacious in clinical practice. One aspect of crucial importance in the physiopathology of stroke which is not completely understood is neuroinflammation. At the present time, it is becoming evident that subtle, but continuous neuroinflammation can provide the ground for disorders such as cerebral small vessel disease. Moreover, advanced aging and a number of highly prevalent risk factors such as obesity, hypertension, diabetes and atherosclerosis could act as "silent contributors" promoting a chronic proinflammatory state. This could aggravate the outcome of various pathological entities and can contribute to a number of subsequent post-stroke complications such as dementia, depression and neurodegeneration creating a pathological vicious cycle. Moreover, recent data suggests that the inflammatory process might be closely linked with multiple neurodegenerative pathways related to depression. In addition, pro-inflammatory cytokines could play a central role in the pathophysiology of both depression and dementia.
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    Journal Title
    Neural Regeneration Research
    Volume
    10
    Issue
    9
    DOI
    https://doi.org/10.4103/1673-5374.165208
    Copyright Statement
    © The Author(s) 2015. This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the original work is cited properly.
    Subject
    Neurosciences
    Neurology and neuromuscular diseases
    Publication URI
    http://hdl.handle.net/10072/101493
    Collection
    • Journal articles

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