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dc.contributor.authorChan, Raymond CK
dc.contributor.authorHuang, Jia
dc.contributor.authorZhao, Qing
dc.contributor.authorWang, Ya
dc.contributor.authorLai, Yun-yao
dc.contributor.authorHong, Nan
dc.contributor.authorShum, David HK
dc.contributor.authorCheung, Eric FC
dc.contributor.authorYu, Xin
dc.contributor.authorDazzan, Paola
dc.date.accessioned2017-10-23T01:53:25Z
dc.date.available2017-10-23T01:53:25Z
dc.date.issued2015
dc.identifier.issn2213-1582
dc.identifier.doi10.1016/j.nicl.2015.09.008
dc.identifier.urihttp://hdl.handle.net/10072/101494
dc.description.abstractNeurological soft signs have been considered one of the promising neurological endophenotypes for schizophrenia. However, most previous studies have employed clinical rating data only. The present study aimed to examine the neurobiological basis of one of the typical motor coordination signs, the Fist–Edge–Palm (FEP) task, in patients with first-episode schizophrenia and their non-psychotic first degree relatives. Thirteen patients with first-episode schizophrenia, 14 non-psychotic first-degree relatives and 14 healthy controls were recruited. All of them were instructed to perform the FEP task in a 3 T GE Machine. Psychophysiological interaction (PPI) analysis was used to evaluate the functional connectivity between the sensorimotor cortex and frontal regions when participants performed the FEP task compared to simple motor tasks. In the contrast of palm-tapping (PT) vs. rest, activation of the left frontal–parietal region was lowest in the schizophrenia group, intermediate in the relative group and highest in the healthy control group. In the contrast of FEP vs. PT, patients with schizophrenia did not show areas of significant activation, while relatives and healthy controls showed significant activation of the left middle frontal gyrus. Moreover, with the increase in task complexity, significant functional connectivity was observed between the sensorimotor cortex and the right frontal gyrus in healthy controls but not in patients with first episode schizophrenia. These findings suggest that activity of the left frontal–parietal and frontal regions may be neurofunctional correlates of neurological soft signs, which in turn may be a potential endophenotype of schizophrenia. Moreover, the right frontal gyrus may play a specific role in the execution of the FEP task in schizophrenia spectrum disorders.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom411
dc.relation.ispartofpageto417
dc.relation.ispartofjournalNeuroImage: Clinical
dc.relation.ispartofvolume9
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode320999
dc.titlePrefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorShum, David
gro.griffith.authorZhao, Qing
gro.griffith.authorChan, Raymond


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