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dc.contributor.authorHardcastle, Sharni Lee
dc.contributor.authorBrenu, Ekua Weba
dc.contributor.authorJohnston, Samantha
dc.contributor.authorThao, Nguyen
dc.contributor.authorHuth, Teilah
dc.contributor.authorRamos, Sandra
dc.contributor.authorStaines, Donald
dc.contributor.authorMarshall-Gradisnik, Sonya
dc.date.accessioned2017-05-05T00:28:21Z
dc.date.available2017-05-05T00:28:21Z
dc.date.issued2015
dc.identifier.issn1449-1907
dc.identifier.doi10.7150/ijms.12399
dc.identifier.urihttp://hdl.handle.net/10072/101600
dc.description.abstractImmunological dysregulation is present in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), with recent studies also highlighting the importance of examining symptom severity. This research addressed this relationship between CFS/ME severity subgroups, assessing serum immunoglobulins and serum cytokines in severe and moderate CFS/ME patients. Participants included healthy controls (n= 22), moderately (n = 22) and severely (n=19) affected CFS/ME patients. The 1994 Fukuda Criteria defined CFS/ME and severity scales confirmed mobile and housebound CFS/ME patients as moderate and severe respectively. IL-1β was significantly reduced in severe compared with moderate CFS/ME patients. IL-6 was significantly decreased in moderate CFS/ME patients compared with healthy controls and severe CFS/ME patients. RANTES was significantly increased in moderate CFS/ME patients compared to severe CFS/ME patients. Serum IL-7 and IL-8 were significantly higher in the severe CFS/ME group compared with healthy controls and moderate CFS/ME patients. IFN-γ was significantly increased in severe CFS/ME patients compared with moderately affected patients. This was the first study to show cytokine variation in moderate and severe CFS/ME patients, with significant differences shown between CFS/ME symptom severity groups. This research suggests that distinguishing severity subgroups in CFS/ME research settings may allow for a more stringent analysis of the heterogeneous and otherwise inconsistent illness.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherIvyspring International Publisher
dc.relation.ispartofpagefrom764
dc.relation.ispartofpageto772
dc.relation.ispartofissue10
dc.relation.ispartofjournalInternational Journal of Medical Sciences
dc.relation.ispartofvolume12
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320499
dc.titleSerum immune proteins in moderate and severe chronic fatigue syndrome/myalgic encephalomyelitis patients
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorStaines, Donald R.
gro.griffith.authorRamos, Sandra B.
gro.griffith.authorMarshall-Gradisnik, Sonya M.


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