dc.contributor.author | Hardcastle, Sharni Lee | |
dc.contributor.author | Brenu, Ekua Weba | |
dc.contributor.author | Johnston, Samantha | |
dc.contributor.author | Thao, Nguyen | |
dc.contributor.author | Huth, Teilah | |
dc.contributor.author | Ramos, Sandra | |
dc.contributor.author | Staines, Donald | |
dc.contributor.author | Marshall-Gradisnik, Sonya | |
dc.date.accessioned | 2017-05-05T00:28:21Z | |
dc.date.available | 2017-05-05T00:28:21Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1449-1907 | |
dc.identifier.doi | 10.7150/ijms.12399 | |
dc.identifier.uri | http://hdl.handle.net/10072/101600 | |
dc.description.abstract | Immunological dysregulation is present in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), with recent studies also highlighting the importance of examining symptom severity. This research addressed this relationship between CFS/ME severity subgroups, assessing serum immunoglobulins and serum cytokines in severe and moderate CFS/ME patients. Participants included healthy controls (n= 22), moderately (n = 22) and severely (n=19) affected CFS/ME patients. The 1994 Fukuda Criteria defined CFS/ME and severity scales confirmed mobile and housebound CFS/ME patients as moderate and severe respectively. IL-1β was significantly reduced in severe compared with moderate CFS/ME patients. IL-6 was significantly decreased in moderate CFS/ME patients compared with healthy controls and severe CFS/ME patients. RANTES was significantly increased in moderate CFS/ME patients compared to severe CFS/ME patients. Serum IL-7 and IL-8 were significantly higher in the severe CFS/ME group compared with healthy controls and moderate CFS/ME patients. IFN-γ was significantly increased in severe CFS/ME patients compared with moderately affected patients. This was the first study to show cytokine variation in moderate and severe CFS/ME patients, with significant differences shown between CFS/ME symptom severity groups. This research suggests that distinguishing severity subgroups in CFS/ME research settings may allow for a more stringent analysis of the heterogeneous and otherwise inconsistent illness. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Ivyspring International Publisher | |
dc.relation.ispartofpagefrom | 764 | |
dc.relation.ispartofpageto | 772 | |
dc.relation.ispartofissue | 10 | |
dc.relation.ispartofjournal | International Journal of Medical Sciences | |
dc.relation.ispartofvolume | 12 | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Immunology not elsewhere classified | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 320499 | |
dc.title | Serum immune proteins in moderate and severe chronic fatigue syndrome/myalgic encephalomyelitis patients | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by-nc/4.0/ | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © The Author(s) 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Staines, Donald R. | |
gro.griffith.author | Ramos, Sandra B. | |
gro.griffith.author | Marshall-Gradisnik, Sonya M. | |