• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • The impact of MTHFR 677 C/T genotypes on folate status markers: a meta-analysis of folic acid intervention studies

    Thumbnail
    View/Open
    ColsonPUB690.pdf (474.4Kb)
    Author(s)
    Colson, Natalie J
    Naug, Helen L
    Nikbakht, Elham
    Zhang, Ping
    McCormack, Joanna
    Griffith University Author(s)
    Naug, Helen L.
    Colson, Natalie J.
    Nikbakht Nasrabadi, Elham
    Zhang, Ping
    McCormack, Jo J.
    Year published
    2017
    Metadata
    Show full item record
    Abstract
    Purpose: Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake. As genetic variability of MTHFR influences folate status, it is important to ensure an adequate intake that overrides genetic effects but minimises any adverse effects. Our aim was to assess the influence of MTHFR genotype on folate status followed by response to supplementation. Methods: We performed a meta-analysis of ten folate intervention studies to assess the degree to which MTHFR C677T genotype influenced plasma ...
    View more >
    Purpose: Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake. As genetic variability of MTHFR influences folate status, it is important to ensure an adequate intake that overrides genetic effects but minimises any adverse effects. Our aim was to assess the influence of MTHFR genotype on folate status followed by response to supplementation. Methods: We performed a meta-analysis of ten folate intervention studies to assess the degree to which MTHFR C677T genotype influenced plasma homocysteine and serum folate levels as measures of folate status. We then examined response after supplementation at intake values up to the upper tolerable limit. Results: The MTHFR 677TT genotype was associated with higher plasma homocysteine (2.7 μmol/L, TT vs. CT/CC; 2.8 μmol/L, TT vs. CC) and lower serum folate (2.5 nmol/L, TT vs. CT/CC; 3.6 nmol/L, TT vs. CC). In two studies, the TT groups had mean plasma Hcy >15 μmol/L. Serum folate levels were >7 nmol/L for all genotype groups. After supplementation of 400 up to 1670 μg DFEs of folic acid or folic acid + fortified foods and/or natural food folates for a minimum of 4 weeks, there were no significant differences in plasma homocysteine levels; however, individuals with the TT genotype had a lower serum folate response to supplementation (7.2 nmol/L, TT vs. CT/CC; 8.7 nmol/L, TT vs. CC). Conclusions: This meta-analysis confirms observations from observational and intervention studies that MTHFR TT genotype is associated with increased plasma homocysteine and lowered serum folate and less response to short-term supplementation. The results can be used for modelling and guiding personalised intake recommendations for the nutrient folate.
    View less >
    Journal Title
    European Journal of Nutrition
    Volume
    56
    Issue
    1
    DOI
    https://doi.org/10.1007/s00394-015-1076-x
    Copyright Statement
    © 2017 Springer Berlin / Heidelberg. This is an electronic version of an article published in European Journal of Nutrition, Volume 56, Issue 1, pp 247–260, 2017. European Journal of Nutrition is available online at: http://link.springer.com/ with the open URL of your article.
    Subject
    Dietetics and Nutrigenomics
    Nutrition and Dietetics
    Publication URI
    http://hdl.handle.net/10072/101654
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander