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dc.contributor.authorDeyou, Tsegaye
dc.contributor.authorGumula, Ivan
dc.contributor.authorPang, Fangfang
dc.contributor.authorGruhonjic, Amra
dc.contributor.authorMumo, Michael
dc.contributor.authorHolleran, John
dc.contributor.authorDuffy, Sandra
dc.contributor.authorFitzpatrick, Paul A
dc.contributor.authorHeydenreich, Matthias
dc.contributor.authorLandberg, Goran
dc.contributor.authorDerese, Solomon
dc.contributor.authorAvery, Vicky
dc.contributor.authorRissanen, Kari
dc.contributor.authorErdelyi, Mate
dc.contributor.authorYenesew, Abiy
dc.date.accessioned2017-11-20T06:22:42Z
dc.date.available2017-11-20T06:22:42Z
dc.date.issued2015
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/acs.jnatprod.5b00581
dc.identifier.urihttp://hdl.handle.net/10072/101696
dc.description.abstractFive new compounds, 4-O-geranylisoliquiritigenin (1), 12-dihydrousararotenoid B (2), 12-dihydrousararotenoid C (3), 4′-O-geranyl-7-hydroxyflavanone (4), and 4′-O-geranyl-7-hydroxydihydroflavanol (5), along with 12 known natural products (6–17) were isolated from the CH2Cl2/MeOH (1:1) extract of the root bark of Millettia usaramensis ssp. usaramensis by chromatographic separation. The purified metabolites were identified by NMR spectroscopic and mass spectrometric analyses, whereas their absolute configurations were established on the basis of chiroptical data and in some cases also by X-ray crystallography. The crude extract was moderately active (IC50 = 11.63 μg/mL) against the ER-negative MDB-MB-231 human breast cancer cell line, and accordingly compounds 6, 8, 9, 10, 12, and 16 also showed moderate to low cytotoxic activities (IC50 25.7–207.2 μM). The new natural product 1 exhibited antiplasmodial activity with IC50 values of 3.7 and 5.3 μM against the chloroquine-sensitive 3D7 and the chloroquine-resistant Dd2 Plasmodium falciparum strains, respectively, and was also cytotoxic to the HEK293 cell line.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofpagefrom2932
dc.relation.ispartofpageto2939
dc.relation.ispartofissue12
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume78
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiochemistry and cell biology not elsewhere classified
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode310199
dc.subject.fieldofresearchcode32
dc.titleRotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorDuffy, Sandra
gro.griffith.authorAvery, Vicky M.


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