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  • NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species

    Author(s)
    Romero, CA
    Grkovic, T
    Han, J
    Zhang, L
    French, JRJ
    Kurtboke, DI
    Quinn, RJ
    Griffith University Author(s)
    Quinn, Ronald J.
    Year published
    2015
    Metadata
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    Abstract
    A new NMR-based method to access to the unique components of the drug-like natural product metabolome of termite-gut associated actinomycetes has been developed. This approach was used to accelerate the identification of lead-like enhanced fractions containing small molecules with unique spectral patterns. The effectiveness of the approach was demonstrated by the isolation and identification of six new natural products, namely, actinoglycosidines A (1) and B (2), actinopolymorphol D (3), niveamycin A (7), B (8) and C (9).A new NMR-based method to access to the unique components of the drug-like natural product metabolome of termite-gut associated actinomycetes has been developed. This approach was used to accelerate the identification of lead-like enhanced fractions containing small molecules with unique spectral patterns. The effectiveness of the approach was demonstrated by the isolation and identification of six new natural products, namely, actinoglycosidines A (1) and B (2), actinopolymorphol D (3), niveamycin A (7), B (8) and C (9).
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    Journal Title
    RSC Advances
    Volume
    5
    Issue
    126
    DOI
    https://doi.org/10.1039/c5ra17553d
    Subject
    Chemical sciences
    Natural products and bioactive compounds
    Publication URI
    http://hdl.handle.net/10072/101751
    Collection
    • Journal articles

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