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dc.contributor.authorYoung, Neil D
dc.contributor.authorChan, Kok-Gan
dc.contributor.authorKorhonen, Pasi K
dc.contributor.authorChong, Teik Min
dc.contributor.authorEe, Robson
dc.contributor.authorMohandas, Namitha
dc.contributor.authorKoehler, Anson V
dc.contributor.authorLim, Yan-Lue
dc.contributor.authorHofmann, Andreas
dc.contributor.authorJex, Aaron R
dc.contributor.authorQian, Baozhen
dc.contributor.authorChilton, Neil B
dc.contributor.authorGobert, Geoffrey N
dc.contributor.authorMcManus, Donald P
dc.contributor.authorTan, Patrick
dc.contributor.authorWebster, Bonnie L
dc.contributor.authorRollinson, David
dc.contributor.authorGasser, Robin B
dc.date.accessioned2017-05-25T05:09:21Z
dc.date.available2017-05-25T05:09:21Z
dc.date.issued2015
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/srep17345
dc.identifier.urihttp://hdl.handle.net/10072/101757
dc.description.abstractSchistosomiasis is a neglected tropical disease that affects more than 200 million people worldwide. The main disease-causing agents, Schistosoma japonicum, S. mansoni and S. haematobium, are blood flukes that have complex life cycles involving a snail intermediate host. In Asia, S. japonicum causes hepatointestinal disease (schistosomiasis japonica) and is challenging to control due to a broad distribution of its snail hosts and range of animal reservoir hosts. In China, extensive efforts have been underway to control this parasite, but genetic variability in S. japonicum populations could represent an obstacle to eliminating schistosomiasis japonica. Although a draft genome sequence is available for S. japonicum, there has been no previous study of molecular variation in this parasite on a genome-wide scale. In this study, we conducted the first deep genomic exploration of seven S. japonicum populations from mainland China, constructed phylogenies using mitochondrial and nuclear genomic data sets, and established considerable variation between some of the populations in genes inferred to be linked to key cellular processes and/or pathogen-host interactions. Based on the findings from this study, we propose that verifying intraspecific conservation in vaccine or drug target candidates is an important first step toward developing effective vaccines and chemotherapies against schistosomiasis.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Macmillan
dc.relation.ispartofpagefrom17345-1
dc.relation.ispartofpageto17345-12
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume5
dc.subject.fieldofresearchBiochemistry and cell biology not elsewhere classified
dc.subject.fieldofresearchcode310199
dc.titleExploring molecular variation in Schistosoma japonicum in China
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2015. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
gro.hasfulltextFull Text
gro.griffith.authorHofmann, Andreas
gro.griffith.authorGobert, Geoffrey N.


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