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dc.contributor.authorBeattie, Karren D
dc.contributor.authorEllwood, Nicola
dc.contributor.authorKumar, Rohitesh
dc.contributor.authorYang, Xinzhou
dc.contributor.authorHealy, Peter C
dc.contributor.authorChoomuenwai, Vanida
dc.contributor.authorQuinn, Ronald J
dc.contributor.authorElliott, Alysha G
dc.contributor.authorHuang, Johnny X
dc.contributor.authorChitty, Jessica L
dc.contributor.authorFraser, James A
dc.contributor.authorCooper, Matthew A
dc.contributor.authorDavis, Rohan A
dc.date.accessioned2021-06-18T03:26:07Z
dc.date.available2021-06-18T03:26:07Z
dc.date.issued2016
dc.identifier.issn0031-9422
dc.identifier.doi10.1016/j.phytochem.2015.12.014
dc.identifier.urihttp://hdl.handle.net/10072/101808
dc.description.abstractEighteen natural products sourced from Australian micro- or macro-fungi were screened for antibacterial and antifungal activity. This focused library was comprised of caprolactams, polyamines, quinones, and polyketides, with additional large-scale isolation studies undertaken in order to resupply previously identified compounds. Chemical investigations of the re-fermented culture from the endophytic fungus Pestalotiopsis sp. yielded three caprolactam analogues, pestalactams D–F, along with larger quantities of the known metabolite pestalactam A, which was methylated using diazomethane to yield 4-O-methylpestalactam A. The chemical structures of the previously undescribed fungal metabolites were determined by analysis of 1D/2D NMR and MS data. The structure of 4-O-methylpestalactam A was confirmed following single crystal X-ray diffraction analysis. The antibacterial and antifungal activity of all compounds was assessed, which identified three compounds, (1S,3R)-austrocortirubin, (1S,3S)-austrocortirubin, and 1-deoxyaustrocortirubin with mild activity (100 μM) against Gram-positive isolates and one compound, 2-hydroxy-6-methyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid, with activity against Cryptococcus neoformans and Cryptococcus gattii at 50 μM.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom79
dc.relation.ispartofpageto85
dc.relation.ispartofjournalPhytochemistry
dc.relation.ispartofvolume124
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchMedicinal and biomolecular chemistry not elsewhere classified
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchPlant biology
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode340499
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode3108
dc.titleAntibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D-F
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionAccepted Manuscript (AM)
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.rights.copyright© 2016 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorHealy, Peter C.
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorDavis, Rohan A.
gro.griffith.authorMitchell, Karren D.


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