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dc.contributor.authorSmith, Daniel J
dc.contributor.authorRamsay, Kay A
dc.contributor.authorYerkovich, Stephanie T
dc.contributor.authorReid, David W
dc.contributor.authorWainwright, Claire E
dc.contributor.authorGrimwood, Keith
dc.contributor.authorBell, Scott C
dc.contributor.authorKidd, Timothy J
dc.date.accessioned2018-04-04T02:54:25Z
dc.date.available2018-04-04T02:54:25Z
dc.date.issued2016
dc.identifier.issn1323-7799
dc.identifier.doi10.1111/resp.12714
dc.identifier.urihttp://hdl.handle.net/10072/101821
dc.description.abstractBackground and objective: In cystic fibrosis (CF), chronic Pseudomonas aeruginosa infection is associated with increased morbidity, antibiotic treatments and mortality. By linking Australian CF registry data with a national microbiological data set, we examined the association between where treatment was delivered, its intensity and P. aeruginosa antibiotic resistance. Methods: Sputa were collected from paediatric and adult CF patients attending 18 Australian CF centres.P. aeruginosa antibiotic susceptibilities determined by local laboratories were correlated with clinical characteristics, treatment intensity and infection with strains commonly shared among Australian CF patients. Between-centre differences in treatment and antibiotic resistance were also compared. Results: Large variations in antibiotic usage, maintenance treatment practices and multi-antibiotic resistant P. aeruginosa (MARPA) prevalence exist between Australian CF centres, although the overall proportions of MARPA isolates were similar in paediatric and adult centres (31% vs 35%, P = 0.29). Among paediatric centres, MARPA correlated with intravenous antibiotic usage and the Australian state where treatment was delivered, while azithromycin, reduced lung function and treating state predicted intravenous antibiotic usage. In adult centres, body mass index (BMI) and treating state were associated with MARPA, while intravenous antibiotic use was predicted by gender, BMI, dornase-alpha, azithromycin, lung function and treating state. In adults, P. aeruginosa strains AUST-01 and AUST-02 independently predicted intravenous antibiotic usage
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing Asia
dc.relation.ispartofpagefrom329
dc.relation.ispartofpageto337
dc.relation.ispartofissue2
dc.relation.ispartofjournalRespirology
dc.relation.ispartofvolume21
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode32
dc.titlePseudomonas aeruginosa antibiotic resistance in Australian cystic fibrosis centres
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorGrimwood, Keith


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