dc.contributor.author | Smith, Daniel J | |
dc.contributor.author | Ramsay, Kay A | |
dc.contributor.author | Yerkovich, Stephanie T | |
dc.contributor.author | Reid, David W | |
dc.contributor.author | Wainwright, Claire E | |
dc.contributor.author | Grimwood, Keith | |
dc.contributor.author | Bell, Scott C | |
dc.contributor.author | Kidd, Timothy J | |
dc.date.accessioned | 2018-04-04T02:54:25Z | |
dc.date.available | 2018-04-04T02:54:25Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1323-7799 | |
dc.identifier.doi | 10.1111/resp.12714 | |
dc.identifier.uri | http://hdl.handle.net/10072/101821 | |
dc.description.abstract | Background and objective: In cystic fibrosis (CF),
chronic Pseudomonas aeruginosa infection is associated
with increased morbidity, antibiotic treatments
and mortality. By linking Australian CF registry data
with a national microbiological data set, we examined
the association between where treatment was delivered,
its intensity and P. aeruginosa antibiotic
resistance.
Methods: Sputa were collected from paediatric and
adult CF patients attending 18 Australian CF centres.P.
aeruginosa antibiotic susceptibilities determined by
local laboratories were correlated with clinical characteristics,
treatment intensity and infection with strains
commonly shared among Australian CF patients.
Between-centre differences in treatment and antibiotic
resistance were also compared.
Results: Large variations in antibiotic usage, maintenance
treatment practices and multi-antibiotic resistant
P. aeruginosa (MARPA) prevalence exist between
Australian CF centres, although the overall proportions
of MARPA isolates were similar in paediatric and adult
centres (31% vs 35%, P = 0.29). Among paediatric
centres, MARPA correlated with intravenous antibiotic
usage and the Australian state where treatment was
delivered, while azithromycin, reduced lung function
and treating state predicted intravenous antibiotic
usage. In adult centres, body mass index (BMI) and
treating state were associated with MARPA, while intravenous
antibiotic use was predicted by gender, BMI,
dornase-alpha, azithromycin, lung function and treating
state. In adults, P. aeruginosa strains AUST-01 and
AUST-02 independently predicted intravenous antibiotic
usage | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Wiley-Blackwell Publishing Asia | |
dc.relation.ispartofpagefrom | 329 | |
dc.relation.ispartofpageto | 337 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | Respirology | |
dc.relation.ispartofvolume | 21 | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearchcode | 32 | |
dc.title | Pseudomonas aeruginosa antibiotic resistance in Australian cystic fibrosis centres | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Grimwood, Keith | |