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  • Nuclear Localization of DNAJB6 Is Associated with Survival of Patients with Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells

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    Accepted Manuscript (AM)
    Author(s)
    Yu, Valen Zhuoyou
    Wong, Victor Chun-Lam
    Dai, Wei
    Ko, Josephine Mun-Yee
    Lam, Alfred King-Yin
    Chan, Kwok Wah
    Samant, Rajeev S
    Lung, Hong Lok
    Shuen, Wai Ho
    Law, Simon
    Chan, Yuen Piu
    Lee, Nikki Pui-Yue
    Tong, Daniel King Hung
    Law, Tsz Ting
    Lee, Victor Ho-Fun
    Lung, Maria Li
    Griffith University Author(s)
    Lam, Alfred K.
    Year published
    2015
    Metadata
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    Abstract
    The DnaJ (Hsp40) homolog, subfamily B, member 6 (DNAJB6) is part of a family of proteins that regulates chaperone activities. One of its isoforms, DNAJB6a, contains a nuclear localization signal and regulates β-catenin signaling during breast cancer development. We investigated the role of DNAJB6 in the pathogenesis of esophageal squamous cell carcinoma (ESCC).The DnaJ (Hsp40) homolog, subfamily B, member 6 (DNAJB6) is part of a family of proteins that regulates chaperone activities. One of its isoforms, DNAJB6a, contains a nuclear localization signal and regulates β-catenin signaling during breast cancer development. We investigated the role of DNAJB6 in the pathogenesis of esophageal squamous cell carcinoma (ESCC).
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    Journal Title
    Gastroenterology
    Volume
    149
    Issue
    7
    DOI
    https://doi.org/10.1053/j.gastro.2015.08.025
    Copyright Statement
    © 2015 AGA Institute. Published by Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Clinical sciences
    Clinical sciences not elsewhere classified
    Neurosciences
    Publication URI
    http://hdl.handle.net/10072/101853
    Collection
    • Journal articles

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