Nuclear Localization of DNAJB6 Is Associated with Survival of Patients with Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells

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Author(s)
Yu, Valen Zhuoyou
Wong, Victor Chun-Lam
Dai, Wei
Ko, Josephine Mun-Yee
Lam, Alfred King-Yin
Chan, Kwok Wah
Samant, Rajeev S
Lung, Hong Lok
Shuen, Wai Ho
Law, Simon
Chan, Yuen Piu
Lee, Nikki Pui-Yue
Tong, Daniel King Hung
Law, Tsz Ting
Lee, Victor Ho-Fun
Lung, Maria Li
Griffith University Author(s)
Year published
2015
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Abstract
The DnaJ (Hsp40) homolog, subfamily B, member 6 (DNAJB6) is part of a family of proteins that regulates chaperone activities. One of its isoforms, DNAJB6a, contains a nuclear localization signal and regulates β-catenin signaling during breast cancer development. We investigated the role of DNAJB6 in the pathogenesis of esophageal squamous cell carcinoma (ESCC).
Journal Title
Gastroenterology
Volume
149
Issue
7
DOI
Copyright Statement
© 2015 AGA Institute. Published by Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
Subject
Clinical sciences
Clinical sciences not elsewhere classified
Neurosciences
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