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dc.contributor.authorSpadaro, Paola A
dc.contributor.authorNaug, Helen L
dc.contributor.authorDu Toit, Eugene F
dc.contributor.authorDonner, Daniel
dc.contributor.authorColson, Natalie J
dc.date.accessioned2018-10-23T06:47:03Z
dc.date.available2018-10-23T06:47:03Z
dc.date.issued2015
dc.identifier.issn0016-6723
dc.identifier.doi10.1017/S0016672315000233
dc.identifier.urihttp://hdl.handle.net/10072/101901
dc.description.abstractConsumption of palatable foods high in refined carbohydrate has been implicated as a contributing factor to the epidemic levels of obesity. Such foods may disrupt appetite regulation in the hypothalamus through alterations in hunger and satiety signalling. This investigation examined whether a palatable high refined carbohydrate (HRC) diet with the potential to induce obesity was linked to modulation of serotonin and dopamine signalling within the hypothalamus of rats. Male Wistar rats were allowed ad libitum access to either a palatable refined carbohydrate enriched (HRC) diet or standard chow (SC). Visceral fat percentage was used as a measure of the animals' weight gain during the trial. Real-time PCR was applied to determine any variation in levels of expression of the serotonin (Slc6A4 or Sert) and dopamine transporter (Slc6A3 or Dat) genes. After 29 weeks, the HRC group showed a significant increase in visceral fat percentage accompanied by increased expression of Sert. Higher levels of circulating triglycerides were also seen. This investigation determined that a refined high carbohydrate diet is associated with visceral obesity, increased circulating lipids in the blood and distorted serotonergic signalling, which possibly alters satiety and hunger signals.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherCambridge University Press
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto6
dc.relation.ispartofissuee23
dc.relation.ispartofjournalGenetics Research
dc.relation.ispartofvolume97
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchGenome structure and regulation
dc.subject.fieldofresearchcode3105
dc.subject.fieldofresearchcode310508
dc.titleA refined high carbohydrate diet is associated with changes in the serotonin pathway and visceral obesity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, Menzies Health Institute
gro.hasfulltextNo Full Text
gro.griffith.authorColson, Natalie J.
gro.griffith.authorDu Toit, Eugene


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