Total synthesis and antiplasmodial activity of pohlianin C and analogues
Author(s)
Lawer, Aggie
Tai, Jonathan
Jolliffe, Katrina A
Fletcher, Sabine
Avery, Vicky M
Hunter, Luke
Year published
2014
Metadata
Show full item recordAbstract
The first synthesis of the glycine-rich cyclic octapeptide pohlianin C is reported, confirming the structure of this natural product. Screening against Plasmodium falciparum reveals moderate antiplasmodial activity, consistent with data obtained from the natural sample. In addition, the synthesis of three analogues reveals that the antiplasmodial activity of pohlianin C can be preserved or increased with simplified structures.The first synthesis of the glycine-rich cyclic octapeptide pohlianin C is reported, confirming the structure of this natural product. Screening against Plasmodium falciparum reveals moderate antiplasmodial activity, consistent with data obtained from the natural sample. In addition, the synthesis of three analogues reveals that the antiplasmodial activity of pohlianin C can be preserved or increased with simplified structures.
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Journal Title
Bioorganic & Medicinal Chemistry Letters
Volume
24
Issue
12
Subject
Medicinal and Biomolecular Chemistry not elsewhere classified
Medicinal and Biomolecular Chemistry
Organic Chemistry
Pharmacology and Pharmaceutical Sciences