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  • Total synthesis and antiplasmodial activity of pohlianin C and analogues

    Author(s)
    Lawer, Aggie
    Tai, Jonathan
    Jolliffe, Katrina A
    Fletcher, Sabine
    Avery, Vicky M
    Hunter, Luke
    Griffith University Author(s)
    Avery, Vicky M.
    Fletcher, Sabine
    Year published
    2014
    Metadata
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    Abstract
    The first synthesis of the glycine-rich cyclic octapeptide pohlianin C is reported, confirming the structure of this natural product. Screening against Plasmodium falciparum reveals moderate antiplasmodial activity, consistent with data obtained from the natural sample. In addition, the synthesis of three analogues reveals that the antiplasmodial activity of pohlianin C can be preserved or increased with simplified structures.The first synthesis of the glycine-rich cyclic octapeptide pohlianin C is reported, confirming the structure of this natural product. Screening against Plasmodium falciparum reveals moderate antiplasmodial activity, consistent with data obtained from the natural sample. In addition, the synthesis of three analogues reveals that the antiplasmodial activity of pohlianin C can be preserved or increased with simplified structures.
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    Journal Title
    Bioorganic & Medicinal Chemistry Letters
    Volume
    24
    Issue
    12
    DOI
    https://doi.org/10.1016/j.bmcl.2014.04.071
    Subject
    Medicinal and Biomolecular Chemistry not elsewhere classified
    Medicinal and Biomolecular Chemistry
    Organic Chemistry
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/102405
    Collection
    • Journal articles

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